This is a lecture delivered by Professor Stefan Knapp of the Structural Genomics Consortium at the University of Oxford, the 2014 winner of the RSC's Rita and John Cornforth Award. The Structural Genomics Consortium was awarded the Rita and John Cornforth Award for world leading collaborative research across the disciplines of structural biology, medicinal chemistry, chemical biology and enzymology towards understanding and exploiting the potential of epigenetics as a target family for future drug discovery.
The topic of the lecture is "Specific targeting of protein interactions mediated by epigenetic reader domains".
Professor Knapp summarises his current research interests:
"Bromodomains (BRDs) are evolutionary conserved protein interaction modules that specifically recognize ε-N-lysine acetylation motifs, a key event in the reading process of epigenetic marks and in the regulation of transcriptional programs. We recently developed an assay and structural biology platform as well as BRD targeted libraries that aid the rational design of specific bromodomain inhibitors. My laboratory is interested in the rational design of specific epigenetic reader domain inhibitors as well as in the characterization of these chemical tools in disease relevant assay systems."
The lecture will take place between 4 and 5pm on 18th March 2015.
The topic of the lecture is "Specific targeting of protein interactions mediated by epigenetic reader domains".
Professor Knapp summarises his current research interests:
"Bromodomains (BRDs) are evolutionary conserved protein interaction modules that specifically recognize ε-N-lysine acetylation motifs, a key event in the reading process of epigenetic marks and in the regulation of transcriptional programs. We recently developed an assay and structural biology platform as well as BRD targeted libraries that aid the rational design of specific bromodomain inhibitors. My laboratory is interested in the rational design of specific epigenetic reader domain inhibitors as well as in the characterization of these chemical tools in disease relevant assay systems."
The lecture will take place between 4 and 5pm on 18th March 2015.
