Although production of new polymorphs and solvates can be a source of profit for companies through extension of the patent lifetime, the inability to manufacture a consistent crystalline form often leads to costly project delays, particularly in chemical development. This conference will focus on these issues from the viewpoint of the process chemist and chemical engineer; i.e. on chemical development issues which impact the ability to routinely manufacture the chosen crystalline form, whether this be the most stable or a metastable crystal.