Biomolecular Simulation 2008, the second annual meeting of the Collaborative Computational Project for Biomolecular Simulation (CCPB), will be held at Bristol Zoo, UK between the 7th and 9th January 2008. The focus of the meeting will be on cutting-edge methods and applications, in particular high accuracy calculations of mechanisms and interactions, methodological developments, multi-level methods, and large-scale simulations.