Health technology assessments (HTAs) of health care goods and services play a vital role in coverage and patient cost-sharing options. Diverse connotations and implementation of evidence-based medicine (EBM) and HTA support disparate decisions and health outcomes across patient populations. This conference will explore current approaches to EBM, address practical issues surrounding implementation, discuss best practices for the United States, Europe, Canada, and other nations, and provide current legal and regulatory guidance.