Together with the SMR award lecture the "Recent Disclosures of Clinical Candidates” meeting features an excellent array of novel molecular therapeutics across several target classes and therapeutic areas, which include oncology (inhibitors of BTK and Mdm2), pain (Nav1.7 modulation), CNS (highly selective M1 agonists and BACE1 inhibitors), bacterial infection (inhibitors of Clostridium difficile) and allergic inflammation (intranasal TLR7 agonists).