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\)Z}M]m~2=]RΡ47wdCɼIsx=XqF&44pu5)t4[Ѻ{t Xfwtm|[ZoުuuM7,fKF*S^ip.IJBchs‘xmI;V׉ZLhmlv*rZ["m LXbG8lMӿ->^[w;nmvltQuD/}`(VPk;\CfBCRlxXKU+k2! xhX4=DioRuNw|ޣF7czCwTS5zSW\Du {#uRmiE=M-< @,SQJuQuB(XpHCc晳4/hͽhi]o^8[,8#!t*՘Ź/Rk(*P'38)"Һ>00 )dbbjwwD"+IVV"dx< }|ohCxjrf7 ĒX:_Z\θ&vTs|l aE t\Y.DŽ0CRHIkϿ߾^_v"vW/km#CK_vyo|_ H3S"!5$Y Q'a@oY$&Ia7p W@;1m&KeLac,˲L6JV؋aۉ4Zk^쳯GGPݻjD ~y}w\R;'"ΉǍABv^Lht.V@%"l-\ IsA (P )4W8 0$Or1c%&E`&OPg,o$I bq+Ӱ?yj?xq:Խz#7+;q~'+O{#wy뤤7@) -@K\2 x8C8 Ԋ nC06)VtNВ@$H񎮑٥43R,-`-x7n] /P~]Ц? ,sQ< endstream endobj 55 0 obj << /Length 69500 >> stream BX q 0.37 0 0 0.37 56.7 -40.32 cm 1 0 0 1 88 -83 cm 2 26.4324 993 2425 re W n 0.502 0.502 0.502 rg h f* 1 1 1 rg h f* 0.251 0.251 0.251 rg h f* 0.8314 0.8157 0.7843 rg h f* 1 1 1 rg 2 2 994 2442 re f 0.2 0.2 0.2 rg 17 2394 970 30 re f q 31 2395 188 24 re W n BT /Fabc6 16 Tf 1 1 1 rg 1 0 0 1 31 2404 Tm 0.0893 Tc -0.5373 Tw (Day One) Tj ET Q q 219 2395 753 29 re W n BT /Fabc6 16 Tf 1 1 1 rg 1 0 0 1 667 2404 Tm 0.0026 Tc -0.4506 Tw (7th Annual Biological Production Forum) Tj ET Q 1 1 1 rg 17 2356 40 38 re f q 17 2356 40 38 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 2379 Tm 0.0404 Tc (08:00) Tj ET Q 1 1 1 rg 57 2356 8 38 re f q 57 2356 8 38 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 2379 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 2356 922 38 re f 0.8 0.8 0.8 RG 1 w 2 J 977.5 2391.5 m 65.5 2391.5 l S q 65 2371 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 65 2375 Tm 0.0512 Tc -0.2212 Tw (Morning coffee) Tj ET Q 1 1 1 rg 57 2346 8 10 re f 1 1 1 rg 65 2346 922 10 re f 1 1 1 rg 17 2294 40 52 re f q 17 2294 40 52 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 2331 Tm 0.0404 Tc (08:30) Tj ET Q 1 1 1 rg 57 2294 8 52 re f q 57 2294 8 52 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 2331 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 2294 922 52 re f 0.8 0.8 0.8 RG 1 w 2 J 977.5 2343.5 m 65.5 2343.5 l S q 65 2323 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 65 2327 Tm -0.1579 Tc -0.0121 Tw (Chairman's opening remarks) Tj ET Q q 65 2294 913 29 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 2297 Tm 0.2492 Tc -0.3072 Tw (Dr. Mark Bustard) Tj ET Q q 65 2294 913 29 re W n BT /Fabc6 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 157 2297 Tm 0.22 Tc (, ) Tj ET Q q 65 2294 913 29 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 163 2297 Tm 0.0953 Tc -0.1533 Tw (Technical Manager) Tj ET Q q 65 2294 913 29 re W n BT /Fabc6 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 258 2297 Tm 0.22 Tc (, ) Tj ET Q q 65 2294 913 29 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 264 2297 Tm 0.1513 Tc (bioProcessUK) Tj ET Q q 65 2294 913 29 re W n BT /Fabc6 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 341 2297 Tm 96.9529 Tz 0.3047 Tw ( UK) Tj ET Q q 65 2294 913 29 re W n BT /Fabc9 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 358 2297 Tm ( ) Tj ET Q 1 1 1 rg 57 2284 8 10 re f 1 1 1 rg 65 2284 922 10 re f 1 1 1 rg 17 2151 40 133 re f q 17 2151 40 133 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 2269 Tm 0.0404 Tc (08:35) Tj ET Q 1 1 1 rg 57 2151 8 133 re f q 57 2151 8 133 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 2269 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 2151 922 133 re f 0.8 0.8 0.8 RG 1 w 2 J 977.5 2281.5 m 65.5 2281.5 l S q 65 2261 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 65 2265 Tm -0.0939 Tc -0.0761 Tw (CREATING THE ALL INCLUSIVE MANUFACTURING PLATFORM) Tj ET Q q 65 2261 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 515 2265 Tm ( ) Tj ET Q q 65 2151 913 110 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 2246 Tm 0.0241 Tc 0.4584 Tw (Case study: Standardised manufacturing platforms ) Tj ET Q q 65 2151 913 110 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 388 2246 Tm 92.4001 Tz (-) Tj ET Q q 65 2151 913 110 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 392 2246 Tm 0.0822 Tc 0.3038 Tw ( seamlessly integrating discovery through to manufacturing and increasing time to market) Tj ET Q q 65 2151 913 110 re W n BT /Fabc10 12 Tf 0.4 0.4 0.4 rg 1 0 0 1 961 2246 Tm ( ) Tj ET Q q 65 2151 913 110 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 2154 Tm 0.1729 Tc -0.2309 Tw (Dr. Jerry Kinzel) Tj ET Q q 65 2151 913 110 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 148 2154 Tm 0.22 Tc (, ) Tj ET Q q 65 2151 913 110 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 154 2154 Tm 0.0361 Tc -0.0941 Tw (Executive Director of Bioproduct Research and Development) Tj ET Q q 65 2151 913 110 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 452 2154 Tm 0.22 Tc (, ) Tj ET Q q 65 2151 913 110 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 458 2154 Tm 95.8719 Tz 0.0682 Tw (Eli Lilly) Tj ET Q q 65 2151 913 110 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 495 2154 Tm 0.1467 Tc 0.0733 Tw ( USA) Tj ET Q q 65 2151 913 110 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 519 2154 Tm ( ) Tj ET Q q 32 0 0 10 65 2233 cm /Iabc13 Do Q q 111 2230 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 2232 Tm 0.2004 Tc -0.0336 Tw (Creating a standardised generic manufacturing platform ) Tj ET Q q 111 2230 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 436 2232 Tm 0.006 Tc (-) Tj ET Q q 111 2230 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 441 2232 Tm 0.1699 Tc -0.0309 Tw ( one size to fit all molecules) Tj ET Q q 111 2230 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 600 2232 Tm ( ) Tj ET Q q 32 0 0 10 65 2219 cm /Iabc17 Do Q q 111 2217 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 2219 Tm 0.1609 Tc -0.0219 Tw (Integrating manufacturing steps from discovery through to manufacturing and modifying molecules to fit platforms) Tj ET Q q 32 0 0 10 65 2206 cm /Iabc21 Do Q q 111 2204 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 2206 Tm 0.1689 Tc -0.0299 Tw (Successful tools and techniques:) Tj ET Q q 111 2204 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 297 2206 Tm 0.2405 Tc -0.0552 Tw ( Bags and disposables ) Tj ET Q q 111 2204 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 428 2206 Tm 0.006 Tc (-) Tj ET Q q 111 2204 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 433 2206 Tm 0.1226 Tc 0.0164 Tw ( eliminating down time and turn around) Tj ET Q q 32 0 0 10 65 2193 cm /Iabc25 Do Q q 111 2191 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 2193 Tm 0.1545 Tc 0.0123 Tw (The flexible facility of the future ) Tj ET Q q 111 2191 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 297 2193 Tm 0.006 Tc (-) Tj ET Q q 111 2191 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 302 2193 Tm 0.2013 Tc -0.0449 Tw ( managing capacity demands and variability in capacity demands ) Tj ET Q q 32 0 0 10 65 2180 cm /Iabc25 Do Q q 111 2178 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 2180 Tm 0.1702 Tc -0.0312 Tw (Implementing successful tech transfer techniques) Tj ET Q 1 1 1 rg 57 2141 8 10 re f 1 1 1 rg 65 2141 922 10 re f 1 1 1 rg 17 2008 40 133 re f q 17 2008 40 133 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 2126 Tm 0.0404 Tc (09:10) Tj ET Q 1 1 1 rg 57 2008 8 133 re f q 57 2008 8 133 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 2126 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 2008 922 133 re f 0.8 0.8 0.8 RG 1 w 2 J 977.5 2138.5 m 65.5 2138.5 l S q 65 2118 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 65 2122 Tm -0.1331 Tc -0.0794 Tw (SUCCESSFUL CAPACITY PLANNING AND UTILISATION ) Tj ET Q q 65 2118 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 463 2122 Tm 0.005 Tc (-) Tj ET Q q 65 2118 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 468 2122 Tm 0.0483 Tc -0.2183 Tw ( BUILDING THE FLEXIBLE FACILITY OF THE FUTURE) Tj ET Q q 65 2008 913 110 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 2103 Tm 0.0953 Tc 0.3679 Tw (Effectively building flexibility throughout manufacturing operations ) Tj ET Q q 65 2008 913 110 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 493 2103 Tm 92.4001 Tz (-) Tj ET Q q 65 2008 913 110 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 497 2103 Tm 0.1131 Tc 0.2729 Tw ( responding to global multi) Tj ET Q q 65 2008 913 110 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 668 2103 Tm 92.4001 Tz (-) Tj ET Q q 65 2008 913 110 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 672 2103 Tm 0.1363 Tc 0.2497 Tw (product demand) Tj ET Q q 65 2008 913 110 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 776 2103 Tm ( ) Tj ET Q q 65 2008 913 110 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 2011 Tm 0.1464 Tc -0.2044 Tw (Michael Cicio) Tj ET Q q 65 2008 913 110 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 137 2011 Tm 0.22 Tc (, ) Tj ET Q q 65 2008 913 110 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 143 2011 Tm -0.0029 Tc -0.0551 Tw (VP Operations and Site Head) Tj ET Q q 65 2008 913 110 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 287 2011 Tm 0.22 Tc (, ) Tj ET Q q 65 2008 913 110 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 293 2011 Tm 0.1101 Tc -0.2261 Tw (Lonza Biologics, ) Tj ET Q q 65 2008 913 110 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 385 2011 Tm 0.1467 Tc (USA) Tj ET Q q 65 2008 913 110 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 406 2011 Tm ( ) Tj ET Q q 32 0 0 10 65 2090 cm /Iabc25 Do Q q 111 2087 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 2089 Tm 0.1702 Tc -0.0312 Tw (High capacity facility design concepts and development) Tj ET Q q 111 2087 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 426 2089 Tm ( ) Tj ET Q q 32 0 0 10 65 2076 cm /Iabc25 Do Q q 111 2074 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 2076 Tm 0.2192 Tc -0.0802 Tw (Transferring current operational excellence know) Tj ET Q q 111 2074 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 392 2076 Tm 0.006 Tc (-) Tj ET Q q 111 2074 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 397 2076 Tm 0.1381 Tc 0.0009 Tw (how into new facility design concepts) Tj ET Q q 32 0 0 10 65 2063 cm /Iabc25 Do Q q 111 2061 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 2063 Tm 0.1518 Tc -0.0128 Tw (Increased throughput through effective equipment utilisation, new hardware capital investment, online dilution and increasing media capacity) Tj ET Q q 32 0 0 10 65 2050 cm /Iabc25 Do Q q 111 2048 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 2050 Tm 0.1732 Tc -0.0342 Tw (Implementing new factors to accommodate higher titer demands and impacts on facility design) Tj ET Q q 32 0 0 10 65 2037 cm /Iabc25 Do Q q 111 2035 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 2037 Tm 0.1607 Tc -0.0217 Tw (Increasing flexibility through disposables: Filters, buffer containers, solution bags, connectors and columns) Tj ET Q 1 1 1 rg 57 1998 8 10 re f 1 1 1 rg 65 1998 922 10 re f 1 1 1 rg 17 1865 40 133 re f q 17 1865 40 133 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 1983 Tm 0.0404 Tc (09:45) Tj ET Q 1 1 1 rg 57 1865 8 133 re f q 57 1865 8 133 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 1983 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 1865 922 133 re f 0.8 0.8 0.8 RG 1 w 2 J 977.5 1995.5 m 65.5 1995.5 l S q 65 1975 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 65 1979 Tm -0.1069 Tc -0.0631 Tw (BUILDING NEW CAPACITY VS. ADVANCED PROCESS IMPROVEMENT STRATEGIES) Tj ET Q q 65 1865 913 110 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1960 Tm 0.0284 Tc 0.3576 Tw (Case study: Avoiding investment into large bioreactor capacity through continuous process improvement) Tj ET Q q 65 1865 913 110 re W n BT /Fabc10 12 Tf 0.4 0.4 0.4 rg 1 0 0 1 727 1960 Tm ( ) Tj ET Q q 65 1865 913 110 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1868 Tm 0.1745 Tc -0.2325 Tw (Patrick Carl) Tj ET Q q 65 1865 913 110 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 128 1868 Tm 0.22 Tc (, ) Tj ET Q q 65 1865 913 110 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 134 1868 Tm 0.0391 Tc -0.0971 Tw (Head of Capacity Management Technical Operations) Tj ET Q q 65 1865 913 110 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 394 1868 Tm 0.22 Tc (, ) Tj ET Q q 65 1865 913 110 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 400 1868 Tm 0.4832 Tc -0.5412 Tw (Merck Serono) Tj ET Q q 65 1865 913 110 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 478 1868 Tm 0.2686 Tc -0.0486 Tw ( Germany) Tj ET Q q 65 1865 913 110 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 524 1868 Tm ( ) Tj ET Q q 32 0 0 10 65 1947 cm /Iabc25 Do Q q 111 1944 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 1946 Tm 0.1708 Tc -0.0318 Tw (Focus on secure supply while continuously reducing both capital investment and operating expenses simultaneously) Tj ET Q q 32 0 0 10 65 1933 cm /Iabc25 Do Q q 111 1931 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 1933 Tm 0.1684 Tc -0.0294 Tw (Increase manufacturing output of existing operations by strengthening the continuous improvement process) Tj ET Q q 111 1931 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 729 1933 Tm ( ) Tj ET Q q 32 0 0 10 65 1920 cm /Iabc25 Do Q q 111 1918 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 1920 Tm 0.1572 Tc -0.0182 Tw (Mitigate the investment risk of building up bioreactor capacity by increasing process stability) Tj ET Q q 32 0 0 10 65 1907 cm /Iabc25 Do Q q 111 1905 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 1907 Tm 0.2032 Tc -0.0642 Tw (Achieve operational excellence in capacity management with best practice sharing and lean six sigma) Tj ET Q q 111 1905 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 693 1907 Tm ( ) Tj ET Q q 32 0 0 10 65 1894 cm /Iabc25 Do Q q 111 1892 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 1894 Tm 0.1944 Tc -0.0554 Tw (What is the impact on demand for bioreactor capacity caused by efficiency gains and the advent of bio) Tj ET Q q 111 1892 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 698 1894 Tm 0.006 Tc (-) Tj ET Q q 111 1892 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 703 1894 Tm 0.1773 Tc -0.0383 Tw (similars and targeted therapies?) Tj ET Q q 111 1892 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 887 1894 Tm ( ) Tj ET Q 1 1 1 rg 57 1855 8 10 re f 1 1 1 rg 65 1855 922 10 re f 1 1 1 rg 17 1817 40 38 re f q 17 1817 40 38 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 1840 Tm 0.0404 Tc (10:20) Tj ET Q 1 1 1 rg 57 1817 8 38 re f q 57 1817 8 38 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 1840 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 1817 922 38 re f 0.8 0.8 0.8 RG 1 w 2 J 977.5 1852.5 m 65.5 1852.5 l S q 65 1832 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 65 1836 Tm 0.0512 Tc -0.2212 Tw (Morning coffee) Tj ET Q 1 1 1 rg 57 1807 8 10 re f 1 1 1 rg 65 1807 922 10 re f 1 1 1 rg 17 1466 40 341 re f q 17 1466 40 341 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 1792 Tm 0.0404 Tc (10:40) Tj ET Q 1 1 1 rg 57 1466 8 341 re f q 57 1466 8 341 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 1792 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 1466 922 341 re f 0.9569 0.9569 0.9569 rg 65 1466 300 341 re f 0.8 0.8 0.8 RG 1 w 2 J 364.5 1806.5 m 65.5 1806.5 l S 0.8 0.8 0.8 rg 65 1766 300 40 re f q 65 1766 300 40 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 65 1789 Tm 0.1012 Tc -0.6612 Tw (Conf room 1 NEXT GENERATION ) Tj ET Q q 65 1766 300 40 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 65 1770 Tm 0.0895 Tc -0.5375 Tw (DISPOSABLE TECHNOLOGIES) Tj ET Q q 65 1466 300 300 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1751 Tm 0.0261 Tc 0.4564 Tw (Disposable technologies of the future ) Tj ET Q q 65 1466 300 300 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 304 1751 Tm 92.4001 Tz (-) Tj ET Q q 65 1466 300 300 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 308 1751 Tm 0.0081 Tc 0.7639 Tw ( outlook ) Tj ET Q q 65 1466 300 300 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1735 Tm 0.0248 Tc 0.4384 Tw (from the Parenteral Drug Association \050PDA\051 ) Tj ET Q q 65 1466 300 300 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1719 Tm -0.0804 Tc 0.4664 Tw (Disposables Task Force) Tj ET Q q 65 1466 300 300 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 213 1719 Tm ( ) Tj ET Q q 32 0 0 10 65 1706 cm /Iabc25 Do Q q 97 1677 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1705 Tm 0.139 Tc 0.0278 Tw (How will current and future regulatory ) Tj ET Q q 97 1677 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1692 Tm 0.1451 Tc 0.0171 Tw (initiatives like QbD drive the introduction of ) Tj ET Q q 97 1677 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1679 Tm 0.1959 Tc -0.0569 Tw (new disposable technologies and systems?) Tj ET Q q 97 1677 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 341 1679 Tm ( ) Tj ET Q q 32 0 0 10 65 1653 cm /Iabc25 Do Q q 97 1638 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1666 Tm 0.2282 Tc -0.0197 Tw (Disposable technology assessments ) Tj ET Q q 97 1638 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 306 1666 Tm 0.006 Tc (-) Tj ET Q q 97 1638 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 311 1666 Tm ( ) Tj ET Q q 97 1638 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1653 Tm 0.1332 Tc 0.0336 Tw (opportunities and threats of new tech ) Tj ET Q q 97 1638 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1640 Tm 0.1281 Tc (implementation ) Tj ET Q q 32 0 0 10 65 1607 cm /Iabc25 Do Q q 97 1586 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1627 Tm 0.1803 Tc -0.0413 Tw (Novel technologies) Tj ET Q q 97 1586 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 204 1627 Tm 0.1447 Tc 0.0406 Tw ( beyond filtration and ) Tj ET Q q 97 1586 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1614 Tm 0.228 Tc (storage ) Tj ET Q q 97 1586 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 144 1614 Tm 0.006 Tc (-) Tj ET Q q 97 1586 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 149 1614 Tm 0.247 Tc -0.0385 Tw ( membrane chromatography, ) Tj ET Q q 97 1586 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1601 Tm 0.1625 Tc 0.0228 Tw (tangential flow systems, disposable ) Tj ET Q q 97 1586 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1588 Tm 0.2282 Tc (bioreactors ) Tj ET Q q 32 0 0 10 65 1568 cm /Iabc25 Do Q q 97 1560 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1575 Tm 0.1981 Tc -0.0128 Tw (Creating more efficient manufacturing ) Tj ET Q q 97 1560 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1562 Tm 0.1647 Tc 0.0438 Tw (practices with disposables ) Tj ET Q q 32 0 0 10 65 1542 cm /Iabc25 Do Q q 97 1534 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1549 Tm 0.1744 Tc -0.0075 Tw (Determining range, scalability and impacts on ) Tj ET Q q 97 1534 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1536 Tm 0.1345 Tc 0.0045 Tw (product licensing) Tj ET Q q 97 1534 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 193 1536 Tm ( ) Tj ET Q q 32 0 0 10 65 1516 cm /Iabc25 Do Q q 97 1508 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1523 Tm 0.1852 Tc -0.0184 Tw (Expanding the use of disposable technology ) Tj ET Q q 97 1508 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1510 Tm 0.1309 Tc 0.1472 Tw (throughout operations ) Tj ET Q q 65 1466 300 42 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1497 Tm 0.2782 Tc -0.3362 Tw (Robert Repetto) Tj ET Q q 65 1466 300 42 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 148 1497 Tm -0.058 Tc (,) Tj ET Q q 65 1466 300 42 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 151 1497 Tm ( ) Tj ET Q q 65 1466 300 42 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 155 1497 Tm 0.0789 Tc -0.1514 Tw (Director, Global New Technology and ) Tj ET Q q 65 1466 300 42 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1483 Tm 0.0156 Tc -0.0736 Tw (Innovation, Manufacturing Sciences & Technology) Tj ET Q q 65 1466 300 42 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 310 1483 Tm -0.058 Tc (,) Tj ET Q q 65 1466 300 42 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 313 1483 Tm ( ) Tj ET Q q 65 1466 300 42 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 317 1483 Tm 0.2 Tc (Wyeth ) Tj ET Q q 65 1466 300 42 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1469 Tm 0.0947 Tc (Biotech) Tj ET Q q 65 1466 300 42 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 106 1469 Tm 0.1467 Tc 0.0733 Tw ( USA) Tj ET Q q 65 1466 300 42 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 130 1469 Tm ( ) Tj ET Q q 365 1466 4 341 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 365 1796 Tm 0.139 Tc (\240) Tj ET Q 0.9569 0.9569 0.9569 rg 369 1466 300 341 re f 0.8 0.8 0.8 RG 1 w 2 J 668.5 1806.5 m 369.5 1806.5 l S 0.8 0.8 0.8 rg 369 1766 300 40 re f q 369 1766 300 40 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 369 1789 Tm 0.1255 Tc -0.6855 Tw (Conf room 2 DEVELOPING THE ) Tj ET Q q 369 1766 300 40 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 369 1770 Tm 0.1767 Tc -0.6247 Tw (SMART REACTORS OF THE FUTURE) Tj ET Q q 369 1766 300 40 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 655 1770 Tm ( ) Tj ET Q q 369 1583 300 182 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1750 Tm 0.0704 Tc 0.3156 Tw (Bigger is not always better:) Tj ET Q q 369 1583 300 182 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 542 1750 Tm 0.0848 Tc 0.4942 Tw ( How optimisation ) Tj ET Q q 369 1583 300 182 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1734 Tm 0.1368 Tc 0.3457 Tw (is replacing maximisation in biologics ) Tj ET Q q 369 1583 300 182 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1718 Tm 0.0114 Tc (production) Tj ET Q q 369 1583 300 182 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 437 1718 Tm ( ) Tj ET Q q 369 1583 300 182 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1600 Tm 0.1012 Tc -0.1592 Tw (Dr. Fadel Hamed) Tj ET Q q 369 1583 300 182 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 457 1600 Tm -0.058 Tc (,) Tj ET Q q 369 1583 300 182 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 460 1600 Tm ( ) Tj ET Q q 369 1583 300 182 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 464 1600 Tm 0.0923 Tc -0.1503 Tw (Head of Operational Excellence) Tj ET Q q 369 1583 300 182 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 621 1600 Tm -0.058 Tc (,) Tj ET Q q 369 1583 300 182 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 624 1600 Tm ( ) Tj ET Q q 369 1583 300 182 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1586 Tm 0.2894 Tc -0.3474 Tw (Genentech Product Operations) Tj ET Q q 369 1583 300 182 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 539 1586 Tm 0.1467 Tc 0.0733 Tw ( USA) Tj ET Q q 369 1583 300 182 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 563 1586 Tm ( ) Tj ET Q q 32 0 0 10 369 1705 cm /Iabc25 Do Q q 401 1702 268 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1704 Tm 0.2336 Tc -0.0714 Tw (Pros and cons of maximise vs. optimise ) Tj ET Q q 32 0 0 10 369 1684 cm /Iabc25 Do Q q 401 1676 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1691 Tm 0.163 Tc 0.0107 Tw (Understanding the overall strategic superiority ) Tj ET Q q 401 1676 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1678 Tm 0.2365 Tc (of) Tj ET Q q 401 1676 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 412 1678 Tm 0.0951 Tc 0.0439 Tw ( optimisation) Tj ET Q q 32 0 0 10 369 1658 cm /Iabc25 Do Q q 401 1650 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1665 Tm 0.1854 Tc -0.0186 Tw (Becoming a nimble production facility capable ) Tj ET Q q 401 1650 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1652 Tm 0.1907 Tc -0.0517 Tw (of meeting variations in customer demand) Tj ET Q q 32 0 0 10 369 1639 cm /Iabc25 Do Q q 401 1637 268 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1639 Tm 0.1685 Tc -0.0295 Tw (Practical optimisation examples and solutions) Tj ET Q q 32 0 0 10 369 1619 cm /Iabc25 Do Q q 401 1611 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1626 Tm 0.1353 Tc 0.0269 Tw (What does the future hold in biologics ) Tj ET Q q 401 1611 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1613 Tm 0.119 Tc (production?) Tj ET Q q 669 1466 4 341 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 669 1796 Tm 0.139 Tc (\240) Tj ET Q 0.9569 0.9569 0.9569 rg 673 1466 301 341 re f 0.8 0.8 0.8 RG 1 w 2 J 973.5 1806.5 m 673.5 1806.5 l S 0.8 0.8 0.8 rg 673 1747 301 59 re f q 673 1747 301 59 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 673 1789 Tm 0.0232 Tc -0.6205 Tw (Conf room 3 FORMULATION ) Tj ET Q q 673 1747 301 59 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 673 1770 Tm 0.0273 Tc -0.6993 Tw (TECHNOLOGIES AVAILABLE FOR ) Tj ET Q q 673 1747 301 59 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 673 1751 Tm -0.0109 Tc -0.6611 Tw (BIOLOGIC UNIT OPERATIONS ) Tj ET Q q 673 1594 301 153 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1732 Tm 0.2807 Tc 0.1053 Tw (Implementing in) Tj ET Q q 673 1594 301 153 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 777 1732 Tm 92.4001 Tz (-) Tj ET Q q 673 1594 301 153 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 781 1732 Tm -0.0541 Tc 0.5688 Tw (line systems to monitor ) Tj ET Q q 673 1594 301 153 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1716 Tm 0.0509 Tc 0.3351 Tw (lyophilised biologics) Tj ET Q q 673 1594 301 153 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 803 1716 Tm ( ) Tj ET Q q 32 0 0 10 673 1703 cm /Iabc25 Do Q q 705 1661 269 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1702 Tm 0.2212 Tc -0.0544 Tw (Overview of available technologies for biologic ) Tj ET Q q 705 1661 269 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1689 Tm 0.1657 Tc 0.0011 Tw (unit operations from incoming raw materials, ) Tj ET Q q 705 1661 269 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1676 Tm 0.1124 Tc 0.0544 Tw (blending in formulation tank, sterile filling, ) Tj ET Q q 705 1661 269 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1663 Tm 0.1335 Tc 0.0055 Tw (lyophilisation, capping and inspection) Tj ET Q q 705 1661 269 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 917 1663 Tm ( ) Tj ET Q q 32 0 0 10 673 1643 cm /Iabc25 Do Q q 705 1635 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1650 Tm 0.1406 Tc -0.0016 Tw (Implementing in) Tj ET Q q 705 1635 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 798 1650 Tm 0.006 Tc (-) Tj ET Q q 705 1635 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 803 1650 Tm 0.1629 Tc 0.0456 Tw (line vacuum detection ) Tj ET Q q 705 1635 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1637 Tm 0.183 Tc -0.044 Tw (technology for a lyophilised biologic) Tj ET Q q 705 1635 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 909 1637 Tm ( ) Tj ET Q q 32 0 0 10 673 1624 cm /Iabc25 Do Q q 705 1622 269 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1624 Tm 0.1391 Tc 0.0694 Tw (Understanding the business ) Tj ET Q q 673 1594 301 28 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1611 Tm -0.0309 Tc -0.0271 Tw (Dr. Ranjit Sarpal) Tj ET Q q 673 1594 301 28 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 758 1611 Tm -0.058 Tc (,) Tj ET Q q 673 1594 301 28 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 761 1611 Tm ( ) Tj ET Q q 673 1594 301 28 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 765 1611 Tm 0.104 Tc -0.191 Tw (Associate Director Manufacturing ) Tj ET Q q 673 1594 301 28 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1597 Tm 0.0141 Tc (Technology) Tj ET Q q 673 1594 301 28 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 730 1597 Tm -0.058 Tc (,) Tj ET Q q 673 1594 301 28 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 733 1597 Tm ( ) Tj ET Q q 673 1594 301 28 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 737 1597 Tm 0.283 Tc -0.341 Tw (Bristol Myers Squibb) Tj ET Q q 673 1594 301 28 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 852 1597 Tm 0.1467 Tc 0.0733 Tw ( USA) Tj ET Q q 673 1594 301 28 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 876 1597 Tm ( ) Tj ET Q q 974 1466 4 341 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 974 1796 Tm 0.139 Tc (\240) Tj ET Q 1 1 1 rg 17 1414 40 52 re f q 17 1414 40 52 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 1451 Tm 0.0404 Tc (11:15) Tj ET Q 1 1 1 rg 57 1414 8 52 re f q 57 1414 8 52 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 1451 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 1414 922 52 re f 0.8 0.8 0.8 RG 1 w 2 J 977.5 1463.5 m 65.5 1463.5 l S q 65 1443 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 65 1447 Tm 0.0983 Tc -0.2683 Tw (IMPLEMENTING NEXT GENERATION DOWNSTREAM METHODOLOGIES) Tj ET Q q 65 1414 913 29 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1417 Tm 0.2036 Tc -0.2616 Tw (Dr. Uwe Gottschalk) Tj ET Q q 65 1414 913 29 re W n BT /Fabc6 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 169 1417 Tm 0.22 Tc (, ) Tj ET Q q 65 1414 913 29 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 175 1417 Tm 0.0904 Tc -0.1484 Tw (Head of Purification Technologies) Tj ET Q q 65 1414 913 29 re W n BT /Fabc6 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 342 1417 Tm 0.22 Tc (, ) Tj ET Q q 65 1414 913 29 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 348 1417 Tm 0.3011 Tc (Sartorius) Tj ET Q q 65 1414 913 29 re W n BT /Fabc6 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 399 1417 Tm 0.0929 Tc 0.1271 Tw ( Germany) Tj ET Q q 65 1414 913 29 re W n BT /Fabc9 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 446 1417 Tm ( ) Tj ET Q 1 1 1 rg 57 1404 8 10 re f 1 1 1 rg 65 1404 922 10 re f 1 1 1 rg 17 1154 40 250 re f q 17 1154 40 250 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 1389 Tm 0.0404 Tc (11:50) Tj ET Q 1 1 1 rg 57 1154 8 250 re f q 57 1154 8 250 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 1389 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 1154 922 250 re f 0.9569 0.9569 0.9569 rg 65 1154 300 250 re f 0.8 0.8 0.8 RG 1 w 2 J 364.5 1403.5 m 65.5 1403.5 l S 0.8 0.8 0.8 rg 65 1344 300 59 re f q 65 1344 300 59 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 65 1386 Tm -0.056 Tc -0.5413 Tw (ADAPTING AND MODIFYING EXISTING ) Tj ET Q q 65 1344 300 59 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 65 1367 Tm 0.1421 Tc -0.8141 Tw (DOWNSTREAM PROCESSES TO ) Tj ET Q q 65 1344 300 59 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 65 1348 Tm 0.0164 Tc -0.4644 Tw (ACCOMMODATE HIGH TITERS) Tj ET Q q 32 0 0 10 65 1332 cm /Iabc25 Do Q q 97 1303 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1331 Tm 0.1968 Tc 0.0117 Tw (Adapting existing processes ) Tj ET Q q 97 1303 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 260 1331 Tm 0.006 Tc (-) Tj ET Q q 97 1303 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 265 1331 Tm ( ) Tj ET Q q 97 1303 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 269 1331 Tm 0.0792 Tc 0.1988 Tw (dealing with ) Tj ET Q q 97 1303 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1318 Tm 0.1663 Tc 0.0005 Tw (very high productivities and higher product ) Tj ET Q q 97 1303 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1305 Tm 0.2508 Tc (demand) Tj ET Q q 97 1303 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 143 1305 Tm ( ) Tj ET Q q 32 0 0 10 65 1279 cm /Iabc25 Do Q q 97 1264 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1292 Tm 0.1299 Tc 0.0555 Tw (Fully exploiting existing technologies ) Tj ET Q q 97 1264 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 309 1292 Tm 0.015 Tc (\226) Tj ET Q q 97 1264 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 316 1292 Tm ( ) Tj ET Q q 97 1264 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 320 1292 Tm 0.1006 Tc (pushing ) Tj ET Q q 97 1264 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1279 Tm 0.1546 Tc 0.0122 Tw (technologies to the edge and understanding ) Tj ET Q q 97 1264 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1266 Tm 0.0792 Tc 0.0598 Tw (the potential and limits) Tj ET Q q 32 0 0 10 65 1246 cm /Iabc25 Do Q q 97 1238 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1253 Tm 0.1586 Tc 0.0082 Tw (Short term vs. long term solutions ) Tj ET Q q 97 1238 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 297 1253 Tm 0.015 Tc (\226) Tj ET Q q 97 1238 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 304 1253 Tm ( ) Tj ET Q q 97 1238 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 308 1253 Tm 0.152 Tc (knowing ) Tj ET Q q 97 1238 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1240 Tm 0.1435 Tc -0.0045 Tw (when and how to invest in new technologies) Tj ET Q q 97 1238 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 348 1240 Tm ( ) Tj ET Q q 32 0 0 10 65 1220 cm /Iabc25 Do Q q 97 1212 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1227 Tm 0.1371 Tc 0.0297 Tw (Evaluating and understanding long term future ) Tj ET Q q 97 1212 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1214 Tm 0.1942 Tc -0.0552 Tw (technology requirements) Tj ET Q q 65 1184 300 28 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1201 Tm 0.226 Tc -0.284 Tw (Dr. Christian Eckermann) Tj ET Q q 65 1184 300 28 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 198 1201 Tm -0.058 Tc (,) Tj ET Q q 65 1184 300 28 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 201 1201 Tm ( ) Tj ET Q q 65 1184 300 28 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 205 1201 Tm 0.0723 Tc -0.1593 Tw (Associate Director, Downstream ) Tj ET Q q 65 1184 300 28 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1187 Tm -0.0728 Tc (Development) Tj ET Q q 65 1184 300 28 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 129 1187 Tm -0.058 Tc (,) Tj ET Q q 65 1184 300 28 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 132 1187 Tm ( ) Tj ET Q q 65 1184 300 28 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 136 1187 Tm 0.3673 Tc -0.4253 Tw (Boehringer Ingelheim) Tj ET Q q 65 1184 300 28 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 256 1187 Tm 0.2686 Tc -0.0486 Tw ( Germany) Tj ET Q q 65 1184 300 28 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 302 1187 Tm ( ) Tj ET Q q 365 1154 4 250 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 365 1393 Tm 0.139 Tc (\240) Tj ET Q 0.9569 0.9569 0.9569 rg 369 1154 300 250 re f 0.8 0.8 0.8 RG 1 w 2 J 668.5 1403.5 m 369.5 1403.5 l S 0.8 0.8 0.8 rg 369 1363 300 40 re f q 369 1363 300 40 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 369 1386 Tm 0.1069 Tc -0.6669 Tw (NEW MEDIUM DESIGN METHODS FOR ) Tj ET Q q 369 1363 300 40 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 369 1367 Tm 0.0688 Tc -0.5168 Tw (MAMMALIAN CELL CULTURE) Tj ET Q q 369 1363 300 40 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 597 1367 Tm ( ) Tj ET Q q 369 1154 300 209 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1348 Tm -0.0288 Tc 0.492 Tw (Wyeth case study: Cell culture process ) Tj ET Q q 369 1154 300 209 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1332 Tm 0.1253 Tc 0.3572 Tw (development for current and future ) Tj ET Q q 369 1154 300 209 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1316 Tm -0.0271 Tc 0.4131 Tw (manufacturing processes) Tj ET Q q 369 1154 300 209 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 527 1316 Tm ( ) Tj ET Q q 32 0 0 10 369 1303 cm /Iabc25 Do Q q 401 1287 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1302 Tm 0.2834 Tc -0.0054 Tw (Process changes ) Tj ET Q q 401 1287 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 500 1302 Tm 0.006 Tc (-) Tj ET Q q 401 1287 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 505 1302 Tm 0.1475 Tc 0.0263 Tw ( determining the effect on ) Tj ET Q q 401 1287 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1289 Tm 0.2094 Tc 0.0686 Tw (manufacturing performance ) Tj ET Q q 32 0 0 10 369 1269 cm /Iabc25 Do Q q 401 1261 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1276 Tm 0.2402 Tc -0.0664 Tw (Continuous process improvements to achieve ) Tj ET Q q 401 1261 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1263 Tm 0.2207 Tc -0.0817 Tw (higher yielding processes) Tj ET Q q 401 1261 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 546 1263 Tm ( ) Tj ET Q q 32 0 0 10 369 1243 cm /Iabc25 Do Q q 401 1235 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1250 Tm 0.186 Tc -0.0007 Tw (Successfully addressing and controlling ) Tj ET Q q 401 1235 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1237 Tm 0.2685 Tc -0.1295 Tw (processs changes) Tj ET Q q 32 0 0 10 369 1211 cm /Iabc25 Do Q q 401 1196 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1224 Tm 0.1525 Tc 0.0143 Tw (Achieving a high productivity cell culture ) Tj ET Q q 401 1196 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1211 Tm 0.196 Tc -0.0292 Tw (processes and determining the effect on ) Tj ET Q q 401 1196 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1198 Tm 0.1513 Tc -0.0123 Tw (manufacturing strategies) Tj ET Q q 369 1154 300 42 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1185 Tm 0.0912 Tc -0.1492 Tw (Dr. Yen) Tj ET Q q 369 1154 300 42 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 408 1185 Tm 0.337 Tc (-) Tj ET Q q 369 1154 300 42 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 412 1185 Tm 0.2296 Tc -0.2876 Tw (Tung Luan) Tj ET Q q 369 1154 300 42 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 470 1185 Tm -0.058 Tc (,) Tj ET Q q 369 1154 300 42 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 473 1185 Tm ( ) Tj ET Q q 369 1154 300 42 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 477 1185 Tm 0.0883 Tc -0.1656 Tw (Principal Engineer II Bioreactor ) Tj ET Q q 369 1154 300 42 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1171 Tm 0.0185 Tc -0.0765 Tw (Process Development/Drug Substance Development) Tj ET Q q 369 1154 300 42 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 627 1171 Tm ( ) Tj ET Q q 369 1154 300 42 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 630 1171 Tm -0.058 Tc (,) Tj ET Q q 369 1154 300 42 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 633 1171 Tm ( ) Tj ET Q q 369 1154 300 42 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1157 Tm 0.1386 Tc -0.1966 Tw (Wyeth Biotech) Tj ET Q q 369 1154 300 42 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 447 1157 Tm 0.1467 Tc 0.0733 Tw ( USA) Tj ET Q q 369 1154 300 42 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 471 1157 Tm ( ) Tj ET Q q 669 1154 4 250 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 669 1393 Tm 0.139 Tc (\240) Tj ET Q 0.9569 0.9569 0.9569 rg 673 1154 301 250 re f 0.8 0.8 0.8 RG 1 w 2 J 973.5 1403.5 m 673.5 1403.5 l S 0.8 0.8 0.8 rg 673 1363 301 40 re f q 673 1363 301 40 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 673 1386 Tm 0.0612 Tc -0.6585 Tw (APPLYING NEAR INFRA RED ) Tj ET Q q 673 1363 301 40 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 673 1367 Tm 0.0573 Tc -0.7293 Tw (SPECTROSCOPY IN FORMULATION ) Tj ET Q q 673 1290 301 72 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1347 Tm 0.0828 Tc 0.3804 Tw (Applying Near Infrared Spectroscopy in the ) Tj ET Q q 673 1290 301 72 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1331 Tm 0.1084 Tc 0.2776 Tw (development of lyophilised formulations) Tj ET Q q 673 1290 301 72 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 928 1331 Tm ( ) Tj ET Q q 673 1290 301 72 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1307 Tm 0.1947 Tc -0.2527 Tw (Dr. Mikael Br\374lls) Tj ET Q q 673 1290 301 72 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 762 1307 Tm -0.058 Tc (,) Tj ET Q q 673 1290 301 72 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 765 1307 Tm ( ) Tj ET Q q 673 1290 301 72 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 769 1307 Tm -0.0434 Tc -0.0146 Tw (Team Head, Product Development) Tj ET Q q 673 1290 301 72 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 937 1307 Tm -0.058 Tc (,) Tj ET Q q 673 1290 301 72 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 940 1307 Tm ( ) Tj ET Q q 673 1290 301 72 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1293 Tm 0.1711 Tc -0.2581 Tw (AstraZeneca R&D M\366lndal ) Tj ET Q q 673 1290 301 72 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 817 1293 Tm 0.3117 Tc (Sweden) Tj ET Q q 673 1290 301 72 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 855 1293 Tm ( ) Tj ET Q q 32 0 0 10 673 1318 cm /Iabc25 Do Q q 974 1154 4 250 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 974 1393 Tm 0.139 Tc (\240) Tj ET Q 1 1 1 rg 17 1116 40 38 re f q 17 1116 40 38 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 1139 Tm 0.0404 Tc (12:25) Tj ET Q 1 1 1 rg 57 1116 8 38 re f q 57 1116 8 38 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 1139 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 1116 922 38 re f 0.8 0.8 0.8 RG 1 w 2 J 977.5 1151.5 m 65.5 1151.5 l S q 65 1131 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 65 1135 Tm -0.0364 Tc -0.1336 Tw (Hosted luncheon) Tj ET Q 1 1 1 rg 57 1106 8 10 re f 1 1 1 rg 65 1106 922 10 re f 1 1 1 rg 17 838 40 268 re f q 17 838 40 268 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 1091 Tm 0.0404 Tc (13:25) Tj ET Q 1 1 1 rg 57 838 8 268 re f q 57 838 8 268 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 1091 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 838 922 268 re f 0.9569 0.9569 0.9569 rg 65 838 300 268 re f 0.8 0.8 0.8 RG 1 w 2 J 364.5 1105.5 m 65.5 1105.5 l S 0.8 0.8 0.8 rg 65 1046 300 59 re f q 65 1046 300 59 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 65 1088 Tm 0.023 Tc -0.6203 Tw (DEPLOYING A DOWNSTREAM COST ) Tj ET Q q 65 1046 300 59 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 65 1069 Tm 0.1045 Tc -1.0005 Tw (REDUCTION STRATEGY ) Tj ET Q q 65 1046 300 59 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 257 1069 Tm 93.8438 Tz (-) Tj ET Q q 65 1046 300 59 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 262 1069 Tm 0.056 Tc -0.952 Tw ( CREATING ) Tj ET Q q 65 1046 300 59 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 65 1050 Tm 0.1701 Tc -1.0661 Tw (TANGIBLE RESULTS ) Tj ET Q q 65 838 300 208 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1031 Tm 0.0636 Tc 0.4189 Tw (Medarex case study: Effectively analysing ) Tj ET Q q 65 838 300 208 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1015 Tm 0.0595 Tc 0.4037 Tw (multiple processes to achieve real cost ) Tj ET Q q 65 838 300 208 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 999 Tm 0.0887 Tc 0.3938 Tw (reduction and increased facility throughput ) Tj ET Q q 32 0 0 10 65 986 cm /Iabc25 Do Q q 97 970 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 985 Tm 0.1965 Tc -0.0227 Tw (Evaluating various processes to understand ) Tj ET Q q 97 970 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 972 Tm 0.125 Tc 0.0835 Tw (cost reduction opportunities ) Tj ET Q q 32 0 0 10 65 946 cm /Iabc25 Do Q q 97 931 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 959 Tm 0.1563 Tc 0.0174 Tw (Understanding and exploiting the enormous ) Tj ET Q q 97 931 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 946 Tm 0.1177 Tc 0.0561 Tw (true cost reduction opportunities in ) Tj ET Q q 97 931 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 933 Tm 0.1954 Tc (downstream) Tj ET Q q 97 931 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 167 933 Tm ( ) Tj ET Q q 32 0 0 10 65 920 cm /Iabc25 Do Q q 97 918 268 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 920 Tm 0.1648 Tc -0.0258 Tw (Implementing single columns) Tj ET Q q 97 918 268 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 264 920 Tm ( ) Tj ET Q q 32 0 0 10 65 907 cm /Iabc25 Do Q q 97 905 268 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 907 Tm 0.1226 Tc 0.0164 Tw (Reducing filtration steps) Tj ET Q q 97 905 268 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 234 907 Tm ( ) Tj ET Q q 32 0 0 10 65 894 cm /Iabc25 Do Q q 97 892 268 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 894 Tm 0.1577 Tc -0.0187 Tw (Replacing flow through with membrane steps) Tj ET Q q 32 0 0 10 65 874 cm /Iabc25 Do Q q 97 866 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 881 Tm 0.2106 Tc -0.0368 Tw (Implementing a realistic change programme ) Tj ET Q q 97 866 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 868 Tm 0.1877 Tc -0.0487 Tw (to reduce costs by 75\045) Tj ET Q q 97 866 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 232 868 Tm ( ) Tj ET Q q 65 838 300 28 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 855 Tm 0.2022 Tc -0.2602 Tw (Dr. Alajari Arunakumari) Tj ET Q q 65 838 300 28 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 192 855 Tm -0.058 Tc (,) Tj ET Q q 65 838 300 28 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 195 855 Tm ( ) Tj ET Q q 65 838 300 28 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 199 855 Tm 0.1327 Tc -0.2197 Tw (Senior Director, Process ) Tj ET Q q 65 838 300 28 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 841 Tm -0.0728 Tc (Development) Tj ET Q q 65 838 300 28 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 129 841 Tm -0.058 Tc (,) Tj ET Q q 65 838 300 28 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 132 841 Tm ( ) Tj ET Q q 65 838 300 28 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 136 841 Tm 0.4819 Tc (Medarex) Tj ET Q q 65 838 300 28 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 184 841 Tm 0.1467 Tc 0.0733 Tw ( USA) Tj ET Q q 65 838 300 28 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 208 841 Tm ( ) Tj ET Q q 365 838 4 268 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 365 1095 Tm 0.139 Tc (\240) Tj ET Q 0.9569 0.9569 0.9569 rg 369 838 300 268 re f 0.8 0.8 0.8 RG 1 w 2 J 668.5 1105.5 m 369.5 1105.5 l S 0.8 0.8 0.8 rg 369 1046 300 59 re f q 369 1046 300 59 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 369 1088 Tm -0.009 Tc -0.551 Tw (CREATING A HIGH INTENSITY mAb ) Tj ET Q q 369 1046 300 59 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 369 1069 Tm 0.112 Tc -0.784 Tw (MANUFACTURING PROCESS WITH ) Tj ET Q q 369 1046 300 59 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 369 1050 Tm 0.0808 Tc -0.9768 Tw (DISPOSABLE TECHNOLGY ) Tj ET Q q 369 933 300 113 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1031 Tm 0.1885 Tc 0.2747 Tw (Integrating a lean approach with disposable ) Tj ET Q q 369 933 300 113 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1015 Tm 94.1837 Tz (systems) Tj ET Q q 369 933 300 113 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 418 1015 Tm ( ) Tj ET Q q 369 933 300 113 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 936 Tm 0.1891 Tc -0.2471 Tw (Dr. James S. Wilson) Tj ET Q q 369 933 300 113 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 477 936 Tm -0.058 Tc (,) Tj ET Q q 369 933 300 113 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 480 936 Tm ( ) Tj ET Q q 369 933 300 113 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 484 936 Tm 0.2018 Tc -0.2598 Tw (Technical Director) Tj ET Q q 369 933 300 113 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 576 936 Tm -0.058 Tc (,) Tj ET Q q 369 933 300 113 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 579 936 Tm ( ) Tj ET Q q 369 933 300 113 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 583 936 Tm 0.3076 Tc (Millipore) Tj ET Q q 369 933 300 113 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 631 936 Tm 0.055 Tc 0.165 Tw ( UK) Tj ET Q q 369 933 300 113 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 648 936 Tm ( ) Tj ET Q q 32 0 0 10 369 1002 cm /Iabc25 Do Q q 401 986 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1001 Tm 0.1592 Tc 0.0146 Tw (Streamlining mAb production for high ) Tj ET Q q 401 986 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 988 Tm 0.0466 Tc (throughput) Tj ET Q q 401 986 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 463 988 Tm ( ) Tj ET Q q 32 0 0 10 369 968 cm /Iabc25 Do Q q 401 960 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 975 Tm 0.2287 Tc -0.0549 Tw (Implementing disposables as a process ) Tj ET Q q 401 960 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 962 Tm 0.2297 Tc (change ) Tj ET Q q 32 0 0 10 369 949 cm /Iabc25 Do Q q 401 947 268 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 949 Tm 0.2217 Tc -0.0827 Tw (Lean six) Tj ET Q q 401 947 268 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 448 949 Tm 0.006 Tc (-) Tj ET Q q 401 947 268 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 453 949 Tm 0.1905 Tc -0.0167 Tw (sigma in a regulated environment ) Tj ET Q q 669 838 4 268 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 669 1095 Tm 0.139 Tc (\240) Tj ET Q 0.9569 0.9569 0.9569 rg 673 838 301 268 re f 0.8 0.8 0.8 RG 1 w 2 J 973.5 1105.5 m 673.5 1105.5 l S 0.8 0.8 0.8 rg 673 1065 301 40 re f q 673 1065 301 40 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 673 1088 Tm 0.0682 Tc -0.6655 Tw (CLINICAL DELIVERY OF HUMAN ) Tj ET Q q 673 1065 301 40 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 673 1069 Tm 0.1293 Tc -0.5773 Tw (EMBRYONIC STEM CELLS) Tj ET Q q 673 963 301 101 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1049 Tm 0.1727 Tc 0.2615 Tw (On the road to the clinical delivery of human ) Tj ET Q q 673 963 301 101 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1033 Tm 0.1321 Tc 0.2539 Tw (embryonic stem cell therapies) Tj ET Q q 673 963 301 101 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 864 1033 Tm ( ) Tj ET Q q 673 963 301 101 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 980 Tm 0.03 Tc -0.088 Tw (Dr. Paul De Sousa) Tj ET Q q 673 963 301 101 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 768 980 Tm -0.058 Tc (,) Tj ET Q q 673 963 301 101 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 771 980 Tm ( ) Tj ET Q q 673 963 301 101 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 775 980 Tm 0.1782 Tc -0.2362 Tw (Chief Scientific Officer) Tj ET Q q 673 963 301 101 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 887 980 Tm -0.058 Tc (,) Tj ET Q q 673 963 301 101 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 890 980 Tm ( ) Tj ET Q q 673 963 301 101 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 894 980 Tm 0.1904 Tc -0.2484 Tw (Roslin Cells) Tj ET Q q 673 963 301 101 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 959 980 Tm ( ) Tj ET Q q 673 963 301 101 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 966 Tm 0.4338 Tc -0.2138 Tw (United Kingdom) Tj ET Q q 673 963 301 101 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 750 966 Tm ( ) Tj ET Q q 32 0 0 10 673 1020 cm /Iabc25 Do Q q 705 1004 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1019 Tm 0.156 Tc 0.0294 Tw (Manufacturing considerations for human ) Tj ET Q q 705 1004 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1006 Tm 0.213 Tc -0.074 Tw (embryonic stem cell therapies) Tj ET Q q 32 0 0 10 673 993 cm /Iabc25 Do Q q 705 991 269 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 993 Tm 0.2357 Tc -0.0967 Tw (Regulatory concerns) Tj ET Q q 974 838 4 268 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 974 1095 Tm 0.139 Tc (\240) Tj ET Q 1 1 1 rg 17 800 40 38 re f q 17 800 40 38 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 823 Tm 0.0404 Tc (14:00) Tj ET Q 1 1 1 rg 57 800 8 38 re f q 57 800 8 38 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 823 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 800 922 38 re f 0.8 0.8 0.8 RG 1 w 2 J 977.5 835.5 m 65.5 835.5 l S q 65 815 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 65 819 Tm 0.2733 Tc (Pre) Tj ET Q q 65 815 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 90 819 Tm 0.005 Tc (-) Tj ET Q q 65 815 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 95 819 Tm 0.0132 Tc -0.1832 Tw (arranged one) Tj ET Q q 65 815 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 190 819 Tm 0.005 Tc (-) Tj ET Q q 65 815 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 195 819 Tm -0.08 Tc (to) Tj ET Q q 65 815 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 209 819 Tm 0.005 Tc (-) Tj ET Q q 65 815 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 214 819 Tm -0.0473 Tc -0.1227 Tw (one meetings) Tj ET Q 1 1 1 rg 57 790 8 10 re f 1 1 1 rg 65 790 922 10 re f 1 1 1 rg 17 463 40 327 re f q 17 463 40 327 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 775 Tm 0.0404 Tc (17:00) Tj ET Q 1 1 1 rg 57 463 8 327 re f q 57 463 8 327 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 775 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 463 922 327 re f 0.9569 0.9569 0.9569 rg 65 463 300 327 re f 0.8 0.8 0.8 RG 1 w 2 J 364.5 789.5 m 65.5 789.5 l S 0.8 0.8 0.8 rg 65 768 300 21 re f q 65 768 300 21 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 65 772 Tm 0.0383 Tc -0.5983 Tw (Conf room 1 Interactive workshop ) Tj ET Q q 54 0 0 40 188 726 cm /Iabc29 Do Q q 65 463 300 262 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 710 Tm 0.0573 Tc 0.3839 Tw (Clearing trace HCP, DNA and viruses in the ) Tj ET Q q 65 463 300 262 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 694 Tm 0.0748 Tc 0.5042 Tw (manufacture of biologics ) Tj ET Q q 65 463 300 262 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 226 694 Tm 7 Tc (\226) Tj ET Q q 65 463 300 262 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 233 694 Tm ( ) Tj ET Q q 65 463 300 262 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 237 694 Tm 0.1362 Tc 0.4428 Tw (Introducing a novel ) Tj ET Q q 65 463 300 262 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 678 Tm 0.255 Tc 0.2275 Tw (single use anion exchange membrane ) Tj ET Q q 65 463 300 262 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 662 Tm 0.0466 Tc (adsorber) Tj ET Q q 65 463 300 262 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 121 662 Tm ( ) Tj ET Q q 65 463 300 262 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 466 Tm 0.3732 Tc -0.4312 Tw (Conrad Maher) Tj ET Q q 65 463 300 262 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 143 466 Tm -0.058 Tc (,) Tj ET Q q 65 463 300 262 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 146 466 Tm ( ) Tj ET Q q 65 463 300 262 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 150 466 Tm -0.0223 Tc -0.0357 Tw (Product Manager) Tj ET Q q 65 463 300 262 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 234 466 Tm -0.058 Tc (,) Tj ET Q q 65 463 300 262 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 237 466 Tm ( ) Tj ET Q q 65 463 300 262 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 241 466 Tm 0.3076 Tc (Millipore) Tj ET Q q 65 463 300 262 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 289 466 Tm ( ) Tj ET Q q 32 0 0 10 65 649 cm /Iabc25 Do Q q 97 620 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 648 Tm 0.2073 Tc -0.0335 Tw (Review of current methodologies and ) Tj ET Q q 97 620 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 635 Tm 0.1378 Tc 0.0359 Tw (limitations in the anion exchange ) Tj ET Q q 97 620 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 622 Tm 0.1759 Tc -0.0369 Tw (chromatography polishing step) Tj ET Q q 97 620 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 273 622 Tm ( ) Tj ET Q q 32 0 0 10 65 589 cm /Iabc25 Do Q q 97 568 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 609 Tm 0.2577 Tc 0.0203 Tw (Introducing ChromaSorb\231 ) Tj ET Q q 97 568 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 254 609 Tm 0.006 Tc (-) Tj ET Q q 97 568 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 259 609 Tm ( ) Tj ET Q q 97 568 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 263 609 Tm 0.4 Tc (a ) Tj ET Q q 97 568 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 596 Tm 0.1773 Tc 0.0312 Tw (chromatographic disposable solution ) Tj ET Q q 97 568 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 583 Tm 0.2347 Tc -0.0679 Tw (combining a porous membrane and a ) Tj ET Q q 97 568 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 570 Tm 0.2022 Tc 0.0063 Tw (proprietary anionic gel ) Tj ET Q q 32 0 0 10 65 544 cm /Iabc25 Do Q q 97 529 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 557 Tm 0.2764 Tc -0.1027 Tw (How ChromaSorb\231 can reduce buffer ) Tj ET Q q 97 529 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 544 Tm 0.1412 Tc 0.0256 Tw (consumption to free up production facilities ) Tj ET Q q 97 529 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 531 Tm 0.1553 Tc -0.0163 Tw (tank capacity constraints) Tj ET Q q 97 529 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 239 531 Tm ( ) Tj ET Q q 32 0 0 10 65 498 cm /Iabc25 Do Q q 97 477 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 518 Tm 0.1999 Tc -0.0145 Tw (How disposable technology provides ) Tj ET Q q 97 477 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 505 Tm 0.1895 Tc -0.0227 Tw (manufacturing facilities ease of use, smaller ) Tj ET Q q 97 477 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 492 Tm 0.1291 Tc 0.0331 Tw (plant footprint and cost savings in validation ) Tj ET Q q 97 477 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 479 Tm 0.1912 Tc -0.0522 Tw (and buffer costs) Tj ET Q q 365 463 4 327 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 365 779 Tm 0.139 Tc (\240) Tj ET Q 0.9569 0.9569 0.9569 rg 369 463 300 327 re f 0.8 0.8 0.8 RG 1 w 2 J 668.5 789.5 m 369.5 789.5 l S 0.8 0.8 0.8 rg 369 768 300 21 re f q 369 768 300 21 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 369 772 Tm 0.0383 Tc -0.4863 Tw (Conf room 2 Interactive workshop) Tj ET Q q 100 0 0 31 469 735 cm /Iabc31 Do Q q 369 517 300 217 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 719 Tm 0.11 Tc 0.276 Tw (Cell culture optimisation) Tj ET Q q 369 517 300 217 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 524 719 Tm ( ) Tj ET Q q 369 517 300 217 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 562 Tm 0.3043 Tc -0.3623 Tw (Frank Wolpers) Tj ET Q q 369 517 300 217 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 449 562 Tm -0.058 Tc (,) Tj ET Q q 369 517 300 217 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 452 562 Tm ( ) Tj ET Q q 369 517 300 217 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 456 562 Tm 0.0999 Tc -0.1579 Tw (Industrial Sales Director Europe) Tj ET Q q 369 517 300 217 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 614 562 Tm -0.058 Tc (,) Tj ET Q q 369 517 300 217 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 617 562 Tm ( ) Tj ET Q q 369 517 300 217 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 548 Tm 0.3066 Tc -0.3646 Tw (ThermoFisher Scientific) Tj ET Q q 369 517 300 217 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 501 548 Tm 0.2686 Tc -0.0486 Tw ( Germany) Tj ET Q q 369 517 300 217 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 547 548 Tm ( ) Tj ET Q q 369 517 300 217 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 551 548 Tm 0.1853 Tc -0.2433 Tw (Brandon L. Pence) Tj ET Q q 369 517 300 217 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 647 548 Tm -0.058 Tc (,) Tj ET Q q 369 517 300 217 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 650 548 Tm ( ) Tj ET Q q 369 517 300 217 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 534 Tm 0.01 Tc -0.068 Tw (BioProduction Market Manager HyClone) Tj ET Q q 369 517 300 217 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 566 534 Tm -0.058 Tc (,) Tj ET Q q 369 517 300 217 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 569 534 Tm ( ) Tj ET Q q 369 517 300 217 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 573 534 Tm 0.471 Tc (ThermoFisher ) Tj ET Q q 369 517 300 217 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 520 Tm 0.1094 Tc (Scientific) Tj ET Q q 369 517 300 217 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 419 520 Tm 0.2686 Tc -0.0486 Tw ( Germany) Tj ET Q q 369 517 300 217 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 465 520 Tm ( ) Tj ET Q q 32 0 0 10 369 706 cm /Iabc25 Do Q q 401 677 268 39 re 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re f q 57 2356 8 38 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 2379 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 2356 922 38 re f 0.8 0.8 0.8 RG 1 w 2 J 977.5 2391.5 m 65.5 2391.5 l S q 65 2371 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 65 2375 Tm 0.0512 Tc -0.2212 Tw (Morning coffee) Tj ET Q 1 1 1 rg 57 2346 8 10 re f 1 1 1 rg 65 2346 922 10 re f 1 1 1 rg 17 2308 40 38 re f q 17 2308 40 38 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 2331 Tm 0.0404 Tc (09:00) Tj ET Q 1 1 1 rg 57 2308 8 38 re f q 57 2308 8 38 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 2331 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 2308 922 38 re f 0.8 0.8 0.8 RG 1 w 2 J 977.5 2343.5 m 65.5 2343.5 l S q 65 2323 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 65 2327 Tm 97.9508 Tz -0.0846 Tw (Chairman's opening remarks and recap of first day) Tj ET Q 1 1 1 rg 57 2298 8 10 re f 1 1 1 rg 65 2298 922 10 re f 1 1 1 rg 17 2246 40 52 re f q 17 2246 40 52 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 2283 Tm 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BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 142 2119 Tm 0.22 Tc (, ) Tj ET Q q 65 2116 913 97 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 148 2119 Tm 0.131 Tc -0.189 Tw (Associate Director Biologics Manufacturing) Tj ET Q q 65 2116 913 97 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 362 2119 Tm 0.22 Tc (, ) Tj ET Q q 65 2116 913 97 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 368 2119 Tm 0.2615 Tc (Abbott) Tj ET Q q 65 2116 913 97 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 405 2119 Tm 0.1467 Tc 0.0733 Tw ( USA) Tj ET Q q 65 2116 913 97 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 429 2119 Tm ( ) Tj ET Q q 32 0 0 10 65 2185 cm /Iabc13 Do Q q 111 2182 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 2184 Tm 0.1777 Tc -0.0387 Tw (Creating a high tech apprentice programme with hands on specific training) Tj ET Q q 32 0 0 10 65 2171 cm /Iabc17 Do Q q 111 2169 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 2171 Tm 0.0896 Tc 0.0693 Tw (Working with institutions to 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ET Q q 65 2083 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 321 2087 Tm 8 Tc (\226) Tj ET Q q 65 2083 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 329 2087 Tm ( ) Tj ET Q q 65 2083 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 333 2087 Tm -0.1027 Tc -0.1523 Tw (MAXIMISING OPERATIONAL EFFICIENCY ) Tj ET Q q 65 1999 913 84 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 2068 Tm 0.0801 Tc 0.3059 Tw (Case study: Centocor, Leiden's lean initiative) Tj ET Q q 65 1999 913 84 re W n BT /Fabc10 12 Tf 0.4 0.4 0.4 rg 1 0 0 1 350 2068 Tm ( ) Tj ET Q q 65 1999 913 84 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 2002 Tm 0.2745 Tc -0.3325 Tw (Gerard Brummelhuis, MSc, MBA) Tj ET Q q 65 1999 913 84 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 241 2002 Tm 0.22 Tc (, ) Tj ET Q q 65 1999 913 84 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 247 2002 Tm 0.1206 Tc -0.1786 Tw (Director Biotech Operations) Tj ET Q q 65 1999 913 84 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 385 2002 Tm 0.22 Tc (, ) Tj ET Q q 65 1999 913 84 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 391 2002 Tm 0.3401 Tc (Centocor) Tj ET Q q 65 1999 913 84 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 442 2002 Tm 0.2757 Tc -0.0557 Tw ( The Netherlands) Tj ET Q q 65 1999 913 84 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 523 2002 Tm ( ) Tj ET Q q 32 0 0 10 65 2055 cm /Iabc21 Do Q q 111 2052 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 2054 Tm 0.2112 Tc -0.0374 Tw (Planning boards vs. computer systems ) Tj ET Q q 111 2052 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 336 2054 Tm 0.015 Tc (\226) Tj ET Q q 111 2052 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 343 2054 Tm ( ) Tj ET Q q 111 2052 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 347 2054 Tm 0.1465 Tc -0.0075 Tw (reducing costs and maximising throughput) Tj ET Q q 111 2052 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 589 2054 Tm ( ) Tj ET Q q 111 2052 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 593 2054 Tm ( ) Tj ET Q q 32 0 0 10 65 2041 cm /Iabc21 Do Q q 111 2039 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 2041 Tm 0.1662 Tc -0.0272 Tw (Transferring tools from the automotives industry to biologics) Tj ET Q q 111 2039 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 457 2041 Tm ( ) Tj ET Q q 32 0 0 10 65 2028 cm /Iabc21 Do Q q 111 2026 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 2028 Tm 0.1541 Tc 0.1239 Tw (Lean tools ) Tj ET Q q 111 2026 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 173 2028 Tm 0.006 Tc (-) Tj ET Q q 111 2026 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 178 2028 Tm ( ) Tj ET Q q 111 2026 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 182 2028 Tm 0.1433 Tc -0.0043 Tw (utilising official schedules and planning boards in biological production) Tj ET Q 1 1 1 rg 57 1989 8 10 re f 1 1 1 rg 65 1989 922 10 re f 1 1 1 rg 17 1951 40 38 re f q 17 1951 40 38 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 1974 Tm 0.0404 Tc (10:55) Tj ET Q 1 1 1 rg 57 1951 8 38 re f q 57 1951 8 38 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 1974 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 1951 922 38 re f 0.8 0.8 0.8 RG 1 w 2 J 977.5 1986.5 m 65.5 1986.5 l S q 65 1966 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 65 1970 Tm 0.0512 Tc -0.2212 Tw (Morning coffee) Tj ET Q 1 1 1 rg 57 1941 8 10 re f 1 1 1 rg 65 1941 922 10 re f 1 1 1 rg 17 1834 40 107 re f q 17 1834 40 107 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 1926 Tm 0.0404 Tc (11:30) Tj ET Q 1 1 1 rg 57 1834 8 107 re f q 57 1834 8 107 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 1926 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 1834 922 107 re f 0.8 0.8 0.8 RG 1 w 2 J 977.5 1938.5 m 65.5 1938.5 l S q 65 1918 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 65 1922 Tm 0.011 Tc -0.181 Tw (NEW METHODOLOGIES FOR CHARACTERISING COMPLEX BIOLOGICAL MOLECULES) Tj ET Q q 65 1918 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 688 1922 Tm ( ) Tj ET Q q 65 1834 913 84 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1903 Tm 0.137 Tc 0.249 Tw (New product characterisation technologies and methodologies for complex biological molecules) Tj ET Q q 65 1834 913 84 re W n BT /Fabc10 12 Tf 0.4 0.4 0.4 rg 1 0 0 1 678 1903 Tm ( ) Tj ET Q q 65 1834 913 84 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1837 Tm 0.1537 Tc -0.2117 Tw (Dr. Andy Pickett) Tj ET Q q 65 1834 913 84 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 152 1837 Tm 0.22 Tc (, ) Tj ET Q q 65 1834 913 84 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 158 1837 Tm 0.1068 Tc -0.1648 Tw (Senior Director Biologicals Science and Technology) Tj ET Q q 65 1834 913 84 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 415 1837 Tm 0.22 Tc (, ) Tj ET Q q 65 1834 913 84 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 421 1837 Tm 0.2805 Tc -0.3385 Tw (Ipsen Biopharm Ltd.) Tj ET Q q 65 1834 913 84 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 532 1837 Tm 0.055 Tc 0.165 Tw ( UK) Tj ET Q q 65 1834 913 84 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 549 1837 Tm ( ) Tj ET Q q 32 0 0 10 65 1890 cm /Iabc21 Do Q q 111 1887 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 1889 Tm 0.1505 Tc -0.0115 Tw (Implementing increasingly sophisticated techniques in biomanufacturing) Tj ET Q q 111 1887 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 522 1889 Tm ( ) Tj ET Q q 32 0 0 10 65 1876 cm /Iabc21 Do Q q 111 1874 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 1876 Tm 0.2321 Tc 0.0459 Tw (Mass spectroscopy ) Tj ET Q q 111 1874 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 222 1876 Tm 0.006 Tc (-) Tj ET Q q 111 1874 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 227 1876 Tm 0.193 Tc -0.054 Tw ( applying small molecule technology to complex biologicals) Tj ET Q q 32 0 0 10 65 1863 cm /Iabc21 Do Q q 111 1861 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 1863 Tm 0.1564 Tc -0.0174 Tw (Is the technology sophisticated enough and what are the future expectations?) Tj ET Q q 111 1861 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 555 1863 Tm ( ) Tj ET Q 1 1 1 rg 57 1824 8 10 re f 1 1 1 rg 65 1824 922 10 re f 1 1 1 rg 17 1588 40 236 re f q 17 1588 40 236 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 1809 Tm 0.0404 Tc (12:05) Tj ET Q 1 1 1 rg 57 1588 8 236 re f q 57 1588 8 236 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 1809 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 1588 922 236 re f 0.9569 0.9569 0.9569 rg 65 1588 300 236 re f 0.8 0.8 0.8 RG 1 w 2 J 364.5 1823.5 m 65.5 1823.5 l S 0.8 0.8 0.8 rg 65 1764 300 59 re f q 65 1764 300 59 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 65 1806 Tm 0.0427 Tc -0.64 Tw (Conf room 1: OPERATIONAL ) Tj ET Q q 65 1764 300 59 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 65 1787 Tm 0.2333 Tc -0.9053 Tw (EXCELLENCE IN VACCINE ) Tj ET Q q 65 1764 300 59 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 65 1768 Tm 0.0622 Tc (MANUFACTURING) Tj ET Q q 65 1764 300 59 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 208 1768 Tm ( ) Tj ET Q q 65 1621 300 143 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1749 Tm 0.1643 Tc 0.2989 Tw (Enhancing efficiency of a commercial viral ) Tj ET Q q 65 1621 300 143 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1733 Tm 0.0118 Tc 0.4707 Tw (vaccine production platform through process ) Tj ET Q q 65 1621 300 143 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1717 Tm 0.0582 Tc (intensification) Tj ET Q q 65 1621 300 143 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 154 1717 Tm ( ) Tj ET Q q 65 1621 300 143 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1638 Tm 0.1944 Tc -0.2524 Tw (Dr. Emile Van Corven) Tj ET Q q 65 1621 300 143 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 180 1638 Tm -0.058 Tc (,) Tj ET Q q 65 1621 300 143 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 183 1638 Tm ( ) Tj ET Q q 65 1621 300 143 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 187 1638 Tm 0.0757 Tc -0.1337 Tw (Director Process Development) Tj ET Q q 65 1621 300 143 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 338 1638 Tm -0.058 Tc (,) Tj ET Q q 65 1621 300 143 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 341 1638 Tm ( ) Tj ET Q q 65 1621 300 143 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1624 Tm 0.2443 Tc (Crucell) Tj ET Q q 65 1621 300 143 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 104 1624 Tm 0.2757 Tc -0.0557 Tw ( The Netherlands) Tj ET Q q 65 1621 300 143 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 185 1624 Tm ( ) Tj ET Q q 32 0 0 10 65 1704 cm /Iabc21 Do Q q 97 1688 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1703 Tm 0.2182 Tc -0.0444 Tw (Developing successful lean concepts and ) Tj ET Q q 97 1688 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1690 Tm 0.2517 Tc (models ) Tj ET Q q 97 1688 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 142 1690 Tm 0.006 Tc (-) Tj ET Q q 97 1688 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 147 1690 Tm 0.199 Tc -0.06 Tw ( reducing costs of goods) Tj ET Q q 97 1688 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 286 1690 Tm ( ) Tj ET Q q 32 0 0 10 65 1670 cm /Iabc21 Do Q q 97 1662 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1677 Tm 0.0902 Tc 0.072 Tw (Moving from 10000 litre to 1000 litre ) Tj ET Q q 97 1662 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1664 Tm 0.2282 Tc (bioreactors ) Tj ET Q q 97 1662 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 165 1664 Tm 0.006 Tc (-) Tj ET Q q 97 1662 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 170 1664 Tm 0.2017 Tc -0.0163 Tw ( achieving real results ) Tj ET Q q 32 0 0 10 65 1651 cm /Iabc21 Do Q q 97 1649 268 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1651 Tm 0.1927 Tc -0.0537 Tw (Achieving a ten) Tj ET Q q 97 1649 268 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 185 1651 Tm 0.006 Tc (-) Tj ET Q q 97 1649 268 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 190 1651 Tm 0.1733 Tc -0.0343 Tw (fold cost of goods reduction) Tj ET Q q 97 1649 268 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 348 1651 Tm ( ) Tj ET Q q 365 1588 4 236 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 365 1813 Tm 0.139 Tc (\240) Tj ET Q 0.9569 0.9569 0.9569 rg 369 1588 300 236 re f 0.8 0.8 0.8 RG 1 w 2 J 668.5 1823.5 m 369.5 1823.5 l S 0.8 0.8 0.8 rg 369 1745 300 78 re f q 369 1745 300 78 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 369 1806 Tm 0.0771 Tc -0.6744 Tw (Conf room 2 DOWNSTREAM ) Tj ET Q q 369 1745 300 78 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 369 1787 Tm 0.2204 Tc -1.1164 Tw (PROCESS DEVELOPMENT ) Tj ET Q q 369 1745 300 78 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 369 1768 Tm 0.076 Tc (STRATEGIES ) Tj ET Q q 369 1745 300 78 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 476 1768 Tm 93.8438 Tz (-) Tj ET Q q 369 1745 300 78 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 481 1768 Tm 0.0234 Tc -0.6954 Tw ( ALLEVIATING THE ) Tj ET Q q 369 1745 300 78 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 369 1749 Tm 0.1366 Tc -0.5846 Tw (CAPACITY CRUNCH) Tj ET Q q 369 1670 300 75 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1730 Tm 0.0759 Tc 0.4388 Tw (Process development methodologies to ) Tj ET Q q 369 1670 300 75 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1714 Tm 0.1736 Tc 0.2124 Tw (alleviate the downstream capacity crunch) Tj ET Q q 369 1670 300 75 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 634 1714 Tm ( ) Tj ET Q q 369 1670 300 75 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1687 Tm -0.0154 Tc -0.0426 Tw (Dr. Hari Pujar) Tj ET Q q 369 1670 300 75 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 439 1687 Tm -0.058 Tc (,) Tj ET Q q 369 1670 300 75 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 442 1687 Tm ( ) Tj ET Q q 369 1670 300 75 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 446 1687 Tm 0.0869 Tc -0.1449 Tw (Head of Bioprocess R & D Outsourcing) Tj ET Q q 369 1670 300 75 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 639 1687 Tm -0.058 Tc (,) Tj ET Q q 369 1670 300 75 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 642 1687 Tm ( ) Tj ET Q q 369 1670 300 75 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1673 Tm 0.4506 Tc -0.5086 Tw (Merck & Co) Tj ET Q q 369 1670 300 75 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 433 1673 Tm 0.1467 Tc 0.0733 Tw ( USA) Tj ET Q q 369 1670 300 75 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 457 1673 Tm ( ) Tj ET Q q 32 0 0 10 369 1701 cm /Iabc21 Do Q q 401 1698 268 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1700 Tm 0.1717 Tc -0.0327 Tw (Addressing the productivity challenge) Tj ET Q q 401 1698 268 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 615 1700 Tm ( ) Tj ET Q q 669 1588 4 236 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 669 1813 Tm 0.139 Tc (\240) Tj ET Q 0.9569 0.9569 0.9569 rg 673 1588 301 236 re f 0.8 0.8 0.8 RG 1 w 2 J 973.5 1823.5 m 673.5 1823.5 l S 0.8 0.8 0.8 rg 673 1764 301 59 re f q 673 1764 301 59 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 673 1806 Tm 0.0895 Tc -0.6495 Tw (Conf room 3 RESPONDING TO ) Tj ET Q q 673 1764 301 59 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 673 1787 Tm -0.0097 Tc -0.6623 Tw (BIOSIMILAR AND BIOGENERIC ) Tj ET Q q 673 1764 301 59 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 673 1768 Tm 0.0224 Tc (REGULATION ) Tj ET Q q 673 1588 301 176 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1749 Tm 0.1284 Tc 0.2576 Tw (Correctly defining similarity and achieving it) Tj ET Q q 673 1588 301 176 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 954 1749 Tm ( ) Tj ET Q q 673 1588 301 176 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1605 Tm 0.1832 Tc -0.2412 Tw (Dr. Keith Chidwick) Tj ET Q q 673 1588 301 176 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 773 1605 Tm -0.058 Tc (,) Tj ET Q q 673 1588 301 176 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 776 1605 Tm ( ) Tj ET Q q 673 1588 301 176 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 780 1605 Tm 0.1349 Tc -0.1929 Tw (Pharmaceutical Assessor) Tj ET Q q 673 1588 301 176 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 907 1605 Tm -0.058 Tc (,) Tj ET Q q 673 1588 301 176 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 910 1605 Tm ( ) Tj ET Q q 673 1588 301 176 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 914 1605 Tm 0.4239 Tc (Medicines ) Tj ET Q q 673 1588 301 176 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1591 Tm 0.1984 Tc -0.2564 Tw (and Healthcare Products Regulatory Agency) Tj ET Q q 673 1588 301 176 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 913 1591 Tm ( ) Tj ET Q q 32 0 0 10 673 1736 cm /Iabc21 Do Q q 705 1707 269 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1735 Tm 0.1866 Tc (Guidelines ) Tj ET Q q 705 1707 269 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 768 1735 Tm 0.015 Tc (\226) Tj ET Q q 705 1707 269 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 775 1735 Tm ( ) Tj ET Q q 705 1707 269 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 779 1735 Tm 0.1634 Tc -0.0013 Tw (claiming similarity is in the eye of ) Tj ET Q q 705 1707 269 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1722 Tm 0.1868 Tc 0.0912 Tw (the beholder ) Tj ET Q q 705 1707 269 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 781 1722 Tm 0.006 Tc (-) Tj ET Q q 705 1707 269 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 786 1722 Tm ( ) Tj ET Q q 705 1707 269 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 790 1722 Tm 0.1462 Tc 0.0275 Tw (addressing the gap in what ) Tj ET Q q 705 1707 269 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1709 Tm 0.2262 Tc -0.0594 Tw (each party believes to be similar ) Tj ET Q q 32 0 0 10 673 1689 cm /Iabc21 Do Q q 705 1681 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1696 Tm 0.1797 Tc -0.0175 Tw (Claiming similarity from a quality and clinical ) Tj ET Q q 705 1681 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1683 Tm 0.244 Tc (perspective) Tj ET Q q 705 1681 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 771 1683 Tm ( ) Tj ET Q q 32 0 0 10 673 1663 cm /Iabc21 Do Q q 705 1655 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1670 Tm 0.1746 Tc -0.0125 Tw (How will pricing models for reimbursement for ) Tj ET Q q 705 1655 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1657 Tm 0.1985 Tc -0.0595 Tw (biogenerics be different to normal generics?) Tj ET Q q 705 1655 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 957 1657 Tm ( ) Tj ET Q q 32 0 0 10 673 1631 cm /Iabc21 Do Q q 705 1616 269 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1644 Tm 0.2379 Tc -0.0525 Tw (US and European markets ) Tj ET Q q 705 1616 269 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 859 1644 Tm 0.006 Tc (-) Tj ET Q q 705 1616 269 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 864 1644 Tm ( ) Tj ET Q q 705 1616 269 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 868 1644 Tm 0.1418 Tc (determining ) Tj ET Q q 705 1616 269 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1631 Tm 0.1625 Tc 0.0112 Tw (lucrative opportunities and different regulatory ) Tj ET Q q 705 1616 269 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1618 Tm 0.2034 Tc (environments) Tj ET Q q 705 1616 269 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 783 1618 Tm ( ) Tj ET Q q 974 1588 4 236 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 974 1813 Tm 0.139 Tc (\240) Tj ET Q 1 1 1 rg 17 1550 40 38 re f q 17 1550 40 38 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 1573 Tm 0.0404 Tc (12:40) Tj ET Q 1 1 1 rg 57 1550 8 38 re f q 57 1550 8 38 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 1573 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 1550 922 38 re f 0.8 0.8 0.8 RG 1 w 2 J 977.5 1585.5 m 65.5 1585.5 l S q 65 1565 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 65 1569 Tm -0.1154 Tc -0.0546 Tw (Themed luncheon discussions) Tj ET Q 1 1 1 rg 57 1540 8 10 re f 1 1 1 rg 65 1540 922 10 re f 1 1 1 rg 17 1208 40 332 re f q 17 1208 40 332 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 1525 Tm 0.0404 Tc (14:00) Tj ET Q 1 1 1 rg 57 1208 8 332 re f q 57 1208 8 332 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 1525 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 1208 922 332 re f 0.9569 0.9569 0.9569 rg 65 1208 300 332 re f 0.8 0.8 0.8 RG 1 w 2 J 364.5 1539.5 m 65.5 1539.5 l S 0.8 0.8 0.8 rg 65 1518 300 21 re f q 65 1518 300 21 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 65 1522 Tm 0.0383 Tc -0.4863 Tw (Conf room 1 Interactive workshop) Tj ET Q q 90 0 0 24 170 1492 cm /Iabc25 Do Q q 65 1351 300 140 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1476 Tm 0.0198 Tc 0.3662 Tw (UNOsphere S and RS:) Tj ET Q q 65 1351 300 140 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 203 1476 Tm ( ) Tj ET Q q 65 1351 300 140 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 207 1476 Tm -0.1623 Tc 0.9343 Tw (TAILORED CATION ) Tj ET Q q 65 1351 300 140 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1460 Tm 97.485 Tz 0.4769 Tw (EXCHANGE RESINS) Tj ET Q q 65 1351 300 140 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 188 1460 Tm ( ) Tj ET Q q 32 0 0 10 65 1447 cm /Iabc21 Do Q q 97 1431 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1446 Tm 0.143 Tc 0.0238 Tw (Studying two cation exchangers with different ) Tj ET Q q 97 1431 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1433 Tm 0.2098 Tc (properties) Tj ET Q q 32 0 0 10 65 1413 cm /Iabc21 Do Q q 97 1405 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1420 Tm 0.1327 Tc 0.041 Tw (Separating proteins with almost identical ) Tj ET Q q 97 1405 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1407 Tm 0.1461 Tc -0.0071 Tw (isoelectric points) Tj ET Q q 32 0 0 10 65 1387 cm /Iabc21 Do Q q 97 1379 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1394 Tm 0.1056 Tc 0.0533 Tw (Running a pH gradient without having to mix ) Tj ET Q q 97 1379 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1381 Tm 0.2174 Tc (buffers) Tj ET Q q 97 1379 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 137 1381 Tm ( ) Tj ET Q q 65 1351 300 28 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1368 Tm 0.2505 Tc -0.3085 Tw (Dr. Mark A. Snyder) Tj ET Q q 65 1351 300 28 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 167 1368 Tm -0.058 Tc (,) Tj ET Q q 65 1351 300 28 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 170 1368 Tm ( ) Tj ET Q q 65 1351 300 28 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 174 1368 Tm 0.0761 Tc -0.1534 Tw (Manager, Process R&D Applications ) Tj ET Q q 65 1351 300 28 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1354 Tm 0.0862 Tc (Group) Tj ET Q q 65 1351 300 28 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 96 1354 Tm -0.058 Tc (,) Tj ET Q q 65 1351 300 28 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 99 1354 Tm ( ) Tj ET Q q 65 1351 300 28 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 103 1354 Tm 95.9314 Tz (Bio) Tj ET Q q 65 1351 300 28 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 120 1354 Tm 0.337 Tc (-) Tj ET Q q 65 1351 300 28 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 124 1354 Tm 0.2396 Tc -0.2976 Tw (Rad Laboratories) Tj ET Q q 65 1351 300 28 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 218 1354 Tm 0.1467 Tc 0.0733 Tw ( USA) Tj ET Q q 65 1351 300 28 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 242 1354 Tm ( ) Tj ET Q q 65 1351 300 28 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 246 1354 Tm ( ) Tj ET Q q 365 1208 4 332 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 365 1529 Tm 0.139 Tc (\240) Tj ET Q 0.9569 0.9569 0.9569 rg 369 1208 300 332 re f 0.8 0.8 0.8 RG 1 w 2 J 668.5 1539.5 m 369.5 1539.5 l S 0.8 0.8 0.8 rg 369 1518 300 21 re f q 369 1518 300 21 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 369 1522 Tm 0.0383 Tc -0.4863 Tw (Conf room 2 Interactive workshop) Tj ET Q q 100 0 0 19 469 1497 cm /Iabc27 Do Q q 369 1340 300 156 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1481 Tm 97.9487 Tz 0.5752 Tw (THE USE OF HIGH THROUGHPUT ) Tj ET Q q 369 1340 300 156 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1465 Tm -0.1475 Tc 0.6622 Tw (TECHNOLOGIES IN PROCESS DEVELOPMENT: ) Tj ET Q q 369 1340 300 156 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1449 Tm -0.1504 Tc 0.5364 Tw (MYTHS AND REALITIES) Tj ET Q q 369 1340 300 156 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 516 1449 Tm ( ) Tj ET Q q 369 1340 300 156 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1357 Tm 0.234 Tc -0.292 Tw (Dr Jonathan Dempsey) Tj ET Q q 369 1340 300 156 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 489 1357 Tm -0.058 Tc (,) Tj ET Q q 369 1340 300 156 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 492 1357 Tm ( ) Tj ET Q q 369 1340 300 156 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 496 1357 Tm 0.1181 Tc -0.1761 Tw (Process Science Fellow) Tj ET Q q 369 1340 300 156 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 615 1357 Tm -0.058 Tc (,) Tj ET Q q 369 1340 300 156 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 618 1357 Tm ( ) Tj ET Q q 369 1340 300 156 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1343 Tm 0.3359 Tc -0.3939 Tw (Invitrogen Limited) Tj ET Q q 369 1340 300 156 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 470 1343 Tm ( ) Tj ET Q q 32 0 0 10 369 1436 cm /Iabc21 Do Q q 401 1420 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1435 Tm 0.1118 Tc 0.0736 Tw (Understanding high throughput technologies ) Tj ET Q q 401 1420 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 656 1435 Tm 0.006 Tc (-) Tj ET Q q 401 1420 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 661 1435 Tm ( ) Tj ET Q q 401 1420 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1422 Tm 0.1775 Tc -0.0385 Tw (do they fit your requirements?) Tj ET Q q 32 0 0 10 369 1402 cm /Iabc21 Do Q q 401 1394 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1409 Tm 0.232 Tc -0.0583 Tw (Overview of upstream and downstream ) Tj ET Q q 401 1394 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1396 Tm 0.1761 Tc -0.0371 Tw (workflows enabling process optimisation) Tj ET Q q 32 0 0 10 369 1376 cm /Iabc21 Do Q q 401 1368 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1383 Tm 0.2558 Tc -0.082 Tw (Accessing larger experimental spaces for ) Tj ET Q q 401 1368 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1370 Tm 0.2146 Tc -0.0756 Tw (improved results) Tj ET Q q 669 1208 4 332 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 669 1529 Tm 0.139 Tc (\240) Tj ET Q 0.9569 0.9569 0.9569 rg 673 1208 301 332 re f 0.8 0.8 0.8 RG 1 w 2 J 973.5 1539.5 m 673.5 1539.5 l S 0.8 0.8 0.8 rg 673 1518 301 21 re f q 673 1518 301 21 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 673 1522 Tm 0.0383 Tc -0.4863 Tw (Conf room 3 Interactive workshop) Tj ET Q q 100 0 0 30 773 1486 cm /Iabc29 Do Q q 673 1208 301 277 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1470 Tm 97.3986 Tz 0.72 Tw (ACHIEVING MANUFACTURING EXCELLENCE ) Tj ET Q q 673 1208 301 277 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1454 Tm -0.1797 Tc 0.6943 Tw (ACROSS THE GLOBAL MANUFACTURING ) Tj ET Q q 673 1208 301 277 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1438 Tm -0.1626 Tc 0.5486 Tw (NETWORK USING AN ON) Tj ET Q q 673 1208 301 277 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 829 1438 Tm 92.4001 Tz (-) Tj ET Q q 673 1208 301 277 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 833 1438 Tm 97.8328 Tz 0.9286 Tw (DEMAND PROCESS ) Tj ET Q q 673 1208 301 277 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1422 Tm -0.1677 Tc 0.5537 Tw (DATA ACCESS AND ANALYTICS PLATFORM) Tj ET Q q 673 1208 301 277 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 949 1422 Tm ( ) Tj ET Q q 673 1208 301 277 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1239 Tm 0.1164 Tc -0.1744 Tw (Dr. Justin O. Neway) Tj ET Q q 673 1208 301 277 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 778 1239 Tm -0.058 Tc (,) Tj ET Q q 673 1208 301 277 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 781 1239 Tm ( ) Tj ET Q q 673 1208 301 277 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 785 1239 Tm 0.1476 Tc -0.2056 Tw (Chief Science Officer) Tj ET Q q 673 1208 301 277 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 891 1239 Tm -0.058 Tc (,) Tj ET Q q 673 1208 301 277 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 894 1239 Tm ( ) Tj ET Q q 673 1208 301 277 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 898 1239 Tm 0.4094 Tc (Aegis ) Tj ET Q q 32 0 0 10 673 1409 cm /Iabc21 Do Q q 705 1393 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1408 Tm 0.2419 Tc -0.1029 Tw (Competitive and regulatory drivers for an on) Tj ET Q q 705 1393 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 962 1408 Tm 0.006 Tc (-) Tj ET Q q 705 1393 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1395 Tm 0.2245 Tc -0.0855 Tw (demand data access platform) Tj ET Q q 705 1393 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 874 1395 Tm ( ) Tj ET Q q 32 0 0 10 673 1375 cm /Iabc21 Do Q q 705 1367 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1382 Tm 0.2082 Tc -0.0494 Tw (Benefits of immediate data access in the same ) Tj ET Q q 705 1367 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1369 Tm 0.142 Tc -0.003 Tw (environment with analytics) Tj ET Q q 705 1367 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 858 1369 Tm ( ) Tj ET Q q 32 0 0 10 673 1349 cm /Iabc21 Do Q q 705 1341 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1356 Tm 0.2247 Tc -0.0857 Tw (Technology aspects of on) Tj ET Q q 705 1341 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 850 1356 Tm 0.006 Tc (-) Tj ET Q q 705 1341 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 855 1356 Tm 0.2088 Tc 0.0692 Tw (demand aggregation ) Tj ET Q q 705 1341 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1343 Tm 0.2138 Tc -0.0748 Tw (of on) Tj ET Q q 705 1341 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 734 1343 Tm 0.006 Tc (-) Tj ET Q q 705 1341 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 739 1343 Tm 0.1682 Tc -0.0292 Tw (line and off) Tj ET Q q 705 1341 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 803 1343 Tm 0.006 Tc (-) Tj ET Q q 705 1341 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 808 1343 Tm 0.136 Tc 0.003 Tw (line data) Tj ET Q q 705 1341 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 857 1343 Tm ( ) Tj ET Q q 32 0 0 10 673 1323 cm /Iabc21 Do Q q 705 1315 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1330 Tm 0.1723 Tc -0.0055 Tw (Leveraging process data in multiple existing ) Tj ET Q q 705 1315 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1317 Tm 0.18 Tc -0.041 Tw (manufacturing systems) Tj ET Q q 705 1315 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 838 1317 Tm ( ) Tj ET Q q 32 0 0 10 673 1297 cm /Iabc21 Do Q q 705 1289 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1304 Tm 0.1861 Tc -0.0471 Tw (The new IT paradigm for multi) Tj ET Q q 705 1289 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 879 1304 Tm 0.006 Tc (-) Tj ET Q q 705 1289 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 884 1304 Tm 0.1387 Tc 0.1393 Tw (site global ) Tj ET Q q 705 1289 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1291 Tm 0.1633 Tc -0.0243 Tw (manufacturing networks) Tj ET Q q 705 1289 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 843 1291 Tm ( ) Tj ET Q q 32 0 0 10 673 1265 cm /Iabc21 Do Q q 705 1250 269 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1278 Tm 0.198 Tc -0.059 Tw (Making the business case for an on) Tj ET Q q 705 1250 269 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 906 1278 Tm 0.006 Tc (-) Tj ET Q q 705 1250 269 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 911 1278 Tm 0.2508 Tc (demand ) Tj ET Q q 705 1250 269 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1265 Tm 0.2186 Tc -0.0518 Tw (data access platform and change management ) Tj ET Q q 705 1250 269 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1252 Tm 0.1813 Tc -0.0423 Tw (for user retooling and realisation of benefits) Tj ET Q q 673 1208 301 28 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1225 Tm 0.1473 Tc -0.2633 Tw (Analytical Corporation ) Tj ET Q q 673 1208 301 28 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 797 1225 Tm 0.1467 Tc (USA) Tj ET Q q 673 1208 301 28 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 818 1225 Tm ( ) Tj ET Q q 673 1208 301 28 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 822 1225 Tm 0.0473 Tc -0.1053 Tw (Randall A. Tatlock) Tj ET Q q 673 1208 301 28 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 918 1225 Tm -0.058 Tc (,) Tj ET Q q 673 1208 301 28 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 921 1225 Tm ( ) Tj ET Q q 673 1208 301 28 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 925 1225 Tm 0.1461 Tc (Associate ) Tj ET Q q 673 1208 301 28 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1211 Tm 0.019 Tc -0.077 Tw (Information Consultant) Tj ET Q q 673 1208 301 28 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 784 1211 Tm -0.058 Tc (,) Tj ET Q q 673 1208 301 28 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 787 1211 Tm ( ) Tj ET Q q 673 1208 301 28 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 791 1211 Tm 0.0299 Tc -0.0879 Tw (Eli Lilly & Company) Tj ET Q q 673 1208 301 28 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 894 1211 Tm 0.1467 Tc 0.0733 Tw ( USA) Tj ET Q q 673 1208 301 28 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 918 1211 Tm ( ) Tj ET Q q 974 1208 4 332 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 974 1529 Tm 0.139 Tc (\240) Tj ET Q 1 1 1 rg 17 928 40 280 re f q 17 928 40 280 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 1193 Tm 0.0404 Tc (15:00) Tj ET Q 1 1 1 rg 57 928 8 280 re f q 57 928 8 280 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 1193 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 928 922 280 re f 0.9569 0.9569 0.9569 rg 65 928 300 280 re f 0.8 0.8 0.8 RG 1 w 2 J 364.5 1207.5 m 65.5 1207.5 l S 0.8 0.8 0.8 rg 65 1186 300 21 re f q 65 1186 300 21 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 65 1190 Tm 0.0383 Tc -0.4863 Tw (Conf room 1 Interactive workshop) Tj ET Q q 65 1047 300 139 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1171 Tm -0.1028 Tc 0.6175 Tw (WHOLE CELL BIOPROCESSING FOR ) Tj ET Q q 65 1047 300 139 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1155 Tm 97.3817 Tz 0.7209 Tw (REGENERATIVE MEDICAL THERAPIES ) Tj ET Q q 65 1047 300 139 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 1050 Tm 0.0846 Tc -0.1426 Tw (Dr. Paul Kemp) Tj ET Q q 65 1047 300 139 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 141 1050 Tm -0.058 Tc (,) Tj ET Q q 65 1047 300 139 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 144 1050 Tm ( ) Tj ET Q q 65 1047 300 139 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 148 1050 Tm 0.1782 Tc -0.2362 Tw (Chief Scientific Officer) Tj ET Q q 65 1047 300 139 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 260 1050 Tm -0.058 Tc (,) Tj ET Q q 65 1047 300 139 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 263 1050 Tm ( ) Tj ET Q q 65 1047 300 139 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 267 1050 Tm 0.3036 Tc (Intercytex) Tj ET Q q 65 1047 300 139 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 322 1050 Tm 0.055 Tc 0.165 Tw ( UK) Tj ET Q q 65 1047 300 139 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 339 1050 Tm ( ) Tj ET Q q 32 0 0 10 65 1142 cm /Iabc21 Do Q q 97 1139 268 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1141 Tm 0.2079 Tc -0.0689 Tw (Bioprocessing considerations) Tj ET Q q 97 1139 268 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 262 1141 Tm ( ) Tj ET Q q 32 0 0 10 65 1121 cm /Iabc21 Do Q q 97 1113 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1128 Tm 0.1168 Tc 0.0685 Tw (Manufacturing steps: Isolation, culture, ) Tj ET Q q 97 1113 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1115 Tm 0.205 Tc -0.0659 Tw (expansion, manufacture and clinical delivery) Tj ET Q q 32 0 0 10 65 1095 cm /Iabc21 Do Q q 97 1087 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1102 Tm 0.1191 Tc 0.043 Tw (Growing cells in conditions that maintain cell ) Tj ET Q q 97 1087 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1089 Tm 0.1679 Tc 0.0058 Tw (functionality to preserve therapeutic effects ) Tj ET Q q 32 0 0 10 65 1069 cm /Iabc21 Do Q q 97 1061 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1076 Tm 0.1522 Tc 0.0563 Tw (Maximising potential development ) Tj ET Q q 97 1061 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 97 1063 Tm 0.1085 Tc (opportunities) Tj ET Q q 365 928 4 280 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 365 1197 Tm 0.139 Tc (\240) Tj ET Q 0.9569 0.9569 0.9569 rg 369 928 300 280 re f 0.8 0.8 0.8 RG 1 w 2 J 668.5 1207.5 m 369.5 1207.5 l S 0.8 0.8 0.8 rg 369 1186 300 21 re f q 369 1186 300 21 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 369 1190 Tm 0.026 Tc -0.586 Tw (conf room 2 Interactive workshop ) Tj ET Q q 369 928 300 258 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1171 Tm 97.8801 Tz 0.6168 Tw (ALTERNATIVE ENABLING TECHNOLOGIES TO ) Tj ET Q q 369 928 300 258 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1155 Tm -0.1065 Tc 0.4925 Tw (OVERCOME LIMITS IN PACKED) Tj ET Q q 369 928 300 258 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 565 1155 Tm 92.4001 Tz (-) Tj ET Q q 369 928 300 258 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 569 1155 Tm 94.7418 Tz 1.1521 Tw ( BED ) Tj ET Q q 369 928 300 258 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 369 1139 Tm 97.6104 Tz (CHROMATOGRAPHY) Tj ET Q q 369 928 300 258 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 498 1139 Tm ( ) Tj ET Q q 32 0 0 10 369 1126 cm /Iabc21 Do Q q 401 1110 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1125 Tm 0.1901 Tc -0.0163 Tw (Determining alternatives to oversized stainless ) Tj ET Q q 401 1110 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1112 Tm 0.1951 Tc -0.0561 Tw (steel columns and buffer requirements) Tj ET Q q 32 0 0 10 369 1086 cm /Iabc21 Do Q q 401 1071 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1099 Tm 0.2039 Tc 0.0046 Tw (Reducing column chromatography ) Tj ET Q q 401 1071 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 600 1099 Tm 0.006 Tc (-) Tj ET Q q 401 1071 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 605 1099 Tm ( ) Tj ET Q q 401 1071 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1086 Tm 0.1797 Tc -0.006 Tw (implementing membrane based flow through ) Tj ET Q q 401 1071 268 39 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1073 Tm 0.2314 Tc (chromatography ) Tj ET Q q 32 0 0 10 369 1040 cm /Iabc21 Do Q q 401 1019 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1060 Tm 0.015 Tc (2) Tj ET Q q 401 1019 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 408 1060 Tm 0.006 Tc (-) Tj ET Q q 401 1019 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 413 1060 Tm 0.1767 Tc -0.0146 Tw (3 column steps, very robust resins, high ) Tj ET Q q 401 1019 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1047 Tm 0.1716 Tc 0.0021 Tw (affinity capture steps, robust chromatography ) Tj ET Q q 401 1019 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1034 Tm 0.1736 Tc 0.0117 Tw (disposable technology, transferring to ) Tj ET Q q 401 1019 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1021 Tm 0.1588 Tc -0.0198 Tw (stainless steel) Tj ET Q q 401 1019 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 481 1021 Tm ( ) Tj ET Q q 32 0 0 10 369 988 cm /Iabc21 Do Q q 401 967 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 1008 Tm 0.2367 Tc -0.0282 Tw (Disposable chromatography focus ) Tj ET Q q 401 967 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 599 1008 Tm 0.006 Tc (-) Tj ET Q q 401 967 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 604 1008 Tm 0.1705 Tc 0.1075 Tw ( alternative ) Tj ET Q q 401 967 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 995 Tm 0.1469 Tc 0.0616 Tw (downstream purification techniques ) Tj ET Q q 401 967 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 607 995 Tm 0.006 Tc (-) Tj ET Q q 401 967 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 612 995 Tm 0.1673 Tc 0.1107 Tw ( column ) Tj ET Q q 401 967 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 982 Tm 0.1443 Tc 0.041 Tw (vs. precipitation and crystallisation ) Tj ET Q q 401 967 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 603 982 Tm 0.006 Tc (-) Tj ET Q q 401 967 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 608 982 Tm ( ) Tj ET Q q 401 967 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 969 Tm 0.12 Tc 0.019 Tw (determining the future) Tj ET Q q 401 967 268 52 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 529 969 Tm ( ) Tj ET Q q 32 0 0 10 369 949 cm /Iabc21 Do Q q 401 941 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 956 Tm 0.1873 Tc -0.002 Tw (Reducing validation requirements for ) Tj ET Q q 401 941 268 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 401 943 Tm 0.1839 Tc -0.0449 Tw (contaminant removal and achieving scalability) Tj ET Q q 669 928 4 280 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 669 1197 Tm 0.139 Tc (\240) Tj ET Q 0.9569 0.9569 0.9569 rg 673 928 301 280 re f 0.8 0.8 0.8 RG 1 w 2 J 973.5 1207.5 m 673.5 1207.5 l S 0.8 0.8 0.8 rg 673 1186 301 21 re f q 673 1186 301 21 re W n BT /Fabc6 16 Tf 0 0 0 rg 1 0 0 1 673 1190 Tm 0.0383 Tc -0.5983 Tw (Conf room 3 Interactive workshop ) Tj ET Q 1 1 1 rg 836 1154 1 30 re f 1 1 1 rg 809 1154 27 1 re f 0.502 0.502 0.502 rg 809 1155 1 29 re f 0.502 0.502 0.502 rg 810 1183 26 1 re f q 14 0 0 16 816 1161 cm /Iabc31 Do Q q 673 1039 301 114 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1138 Tm -0.1092 Tc 0.5917 Tw (DESIGN SPACE FROM A MULTIVARIATE ) Tj ET Q q 673 1039 301 114 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1122 Tm -0.0895 Tc 0.4755 Tw (BIOPHARM PROCESS) Tj ET Q q 673 1039 301 114 re W n BT /Fabc6 13 Tf 0.2 0.2 0.2 rg 1 0 0 1 810 1122 Tm ( ) Tj ET Q q 673 1039 301 114 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1056 Tm 0.0368 Tc -0.0948 Tw (Dr. Ing) Tj ET Q q 673 1039 301 114 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 708 1056 Tm 0.337 Tc (-) Tj ET Q q 673 1039 301 114 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 712 1056 Tm 0.3616 Tc -0.4196 Tw (Marie Olsson) Tj ET Q q 673 1039 301 114 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 785 1056 Tm -0.058 Tc (,) Tj ET Q q 673 1039 301 114 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 788 1056 Tm ( ) Tj ET Q q 673 1039 301 114 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 792 1056 Tm 0.149 Tc -0.207 Tw (Application Specialist) Tj ET Q q 673 1039 301 114 re W n BT /Fabc10 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 899 1056 Tm -0.058 Tc (,) Tj ET Q q 673 1039 301 114 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 902 1056 Tm ( ) Tj ET Q q 673 1039 301 114 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 906 1056 Tm 0.2047 Tc -0.2627 Tw (Umetrics AB) Tj ET Q q 673 1039 301 114 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 974 1056 Tm ( ) Tj ET Q q 673 1039 301 114 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 673 1042 Tm 0.3117 Tc (Sweden) Tj ET Q q 673 1039 301 114 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 711 1042 Tm ( ) Tj ET Q q 32 0 0 10 673 1109 cm /Iabc21 Do Q q 705 1106 269 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1108 Tm 0.1407 Tc -0.0017 Tw (Multivariate technology in practice) Tj ET Q q 32 0 0 10 673 1095 cm /Iabc21 Do Q q 705 1093 269 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1095 Tm 0.2385 Tc -0.0995 Tw (Practical ideas from performed projects) Tj ET Q q 32 0 0 10 673 1075 cm /Iabc21 Do Q q 705 1067 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1082 Tm 0.1777 Tc -0.0039 Tw (Design space visualisation and continuous ) Tj ET Q q 705 1067 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 705 1069 Tm 0.2106 Tc (improvement.) Tj ET Q q 705 1067 269 26 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 785 1069 Tm ( ) Tj ET Q q 974 928 4 280 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 974 1197 Tm 0.139 Tc (\240) Tj ET Q 1 1 1 rg 17 824 40 104 re f q 17 824 40 104 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 19 913 Tm 0.0404 Tc (16:00) Tj ET Q 1 1 1 rg 57 824 8 104 re f q 57 824 8 104 re W n BT /Fabc6 14 Tf 0.2 0.2 0.2 rg 1 0 0 1 59 913 Tm 0.108 Tc (\240) Tj ET Q 1 1 1 rg 65 824 922 104 re f 0.8 0.8 0.8 RG 1 w 2 J 977.5 925.5 m 65.5 925.5 l S q 65 905 913 20 re W n BT /Fabc6 15 Tf 0.6 0 0 rg 1 0 0 1 65 909 Tm -0.0434 Tc -0.1266 Tw (SUCCESSFULLY ACHIEVING LEAN PROTEIN DEVELOPMENT) Tj ET Q q 65 824 913 81 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 65 827 Tm 0.2494 Tc -0.3074 Tw (Dr. Berthold B\366deker) Tj ET Q q 65 824 913 81 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 180 827 Tm 0.22 Tc (, ) Tj ET Q q 65 824 913 81 re W n BT /Fabc7 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 186 827 Tm 0.1483 Tc -0.2063 Tw (Head, Cell Culture & Pilot Facilities) Tj ET Q q 65 824 913 81 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 361 827 Tm 0.22 Tc (, ) Tj ET Q q 65 824 913 81 re W n BT /Fabc6 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 367 827 Tm 0.0993 Tc -0.1573 Tw (Bayer Healthcare AG) Tj ET Q q 65 824 913 81 re W n BT /Fabc10 10 Tf 0.2 0.2 0.2 rg 1 0 0 1 478 827 Tm 0.2686 Tc -0.0486 Tw ( Germany) Tj ET Q q 65 824 913 81 re W n BT /Fabc12 11 Tf 0.2 0.2 0.2 rg 1 0 0 1 524 827 Tm ( ) Tj ET Q q 32 0 0 10 65 893 cm /Iabc21 Do Q q 111 890 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 111 892 Tm 0.1608 Tc 0.0477 Tw (Streamlining bioproduction R&D ) Tj ET Q q 111 890 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 297 892 Tm 0.006 Tc (-) Tj ET Q q 111 890 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 302 892 Tm ( ) Tj ET Q q 111 890 867 13 re W n BT /Fabc12 11 Tf 0.4 0.4 0.4 rg 1 0 0 1 306 892 Tm 0.1611 Tc -0.0221 Tw (cutting down development steps to speed proteins to market) Tj ET Q q 111 890 867 13 re W n 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