The importance of DNA methylation has been intensely studied over many years. Recently the dichotomy of cytosine:methyl cytosine was shattered by the discovery of 5-hydroxymethylcytosine (5-hmC) in mammalian genomic DNA. Produced by oxidation of 5-methylcytosine by the TET family of enzymes, this "new” epigenetic modification is a major focus of epigenetics research with potential roles in development and differentiation through transcriptional regulation and demethylation.
The New Epigenetic Mark: 5-Hydroxymethylcytosine – What is its Function?
13 June 2013, Cambridge, United Kingdom
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Cancer Research UK Cambridge Institute
Cancer Research UK Cambridge Institute, Robinson Way, University of Cambridge, Cambridge, CB2 0RE, United Kingdom
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Biochemical Society
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