Scientific investigations involve changing a number of controlled variables to direct the response in question towards a desired level. Design of Experiments (DOE) is a rational and cost-effective approach to practical experimentation that allows the effect of variables to be assessed using only the minimum of resources. DOE is the backbone for efficient QbD implementation strategies. The final specifications for a region where all specifications are fulfilled to a defined risk level is called Design Space.The course is composed of lectures, demonstrations and computer exercises in software MODDE® based on real life investigations.