A webinar sharing Euroapi's progress in improving the sustainability of the synthesis and purification of the peptides they manufacture.
In response to the need for more sustainable practices in peptide synthesis, particularly in the context of solid phase peptide synthesis (SPPS), the webinar introduces a transformative approach toward achieving sustainability. This work combines, for the first time, the use of Raman spectroscopy as a
process analytical tool (PAT) for real-time monitoring and optimization of reaction steps and substitution of environmentally concerning N,N-dimethylformamide (DMF) with a green solvent
mixture of dimethyl sulfoxide (DMSO) and ethyl acetate (EtOAc). Assuming that in SPPS, the synthetic intermediates are not isolated, the utilization of PAT provides robust and high-resolution
analytics to enable precise control of reaction end points, which allows for timely adjustments, leading to accelerated development, reduction of waste generation, and enhanced reaction efficiency.
Additionally, SpinChem, a unique design of a rotating bed reactor, is introduced as an alternative reactor, which also enables easy integration of PATs to perform solid-phase synthesis.
In response to the need for more sustainable practices in peptide synthesis, particularly in the context of solid phase peptide synthesis (SPPS), the webinar introduces a transformative approach toward achieving sustainability. This work combines, for the first time, the use of Raman spectroscopy as a
process analytical tool (PAT) for real-time monitoring and optimization of reaction steps and substitution of environmentally concerning N,N-dimethylformamide (DMF) with a green solvent
mixture of dimethyl sulfoxide (DMSO) and ethyl acetate (EtOAc). Assuming that in SPPS, the synthetic intermediates are not isolated, the utilization of PAT provides robust and high-resolution
analytics to enable precise control of reaction end points, which allows for timely adjustments, leading to accelerated development, reduction of waste generation, and enhanced reaction efficiency.
Additionally, SpinChem, a unique design of a rotating bed reactor, is introduced as an alternative reactor, which also enables easy integration of PATs to perform solid-phase synthesis.
