DNA sequencing technology has undergone a revolution to achieve over a million-fold improvement in efficiency of data generation. There is now an opportunity for routine adoption of genome sequencing in research and healthcare. Genomes are decoded in a single rapid test that provides improved disease diagnosis to aid treatment. Early applications, include rare, undiagnosed genetic diseases and cancer, exemplified by the 100,000 Genomes project with Genomics England and the National Health Service. The same approach will help widespread implementation of risk profiling, early detection and potentially prevention of cases of common disease in national populations, as healthcare evolves to embrace precision medicine. This technology is being used to sequence the SARS-Cov-2 (Covid19) virus and its variants