RSC Desktop Seminars in Organic 91AV with the Brazilian Chemical Society 2020 are an initiative from the 91AV and the Brazilian Chemical Society to bring cutting-edge research directly to you!
COVID-19 has exposed us to a new reality where the virtual world is much more important than before. In order to keep our students engaged at the frontiers of Organic 91AV, we have organized a weekly webinar series that is a joint collaboration between the 91AV (RSC) and the Organic 91AV Division of the Brazilian Chemical Society (SBQ). It is an alternative way to share work and interact with potential collaborators.
The sections will alternate between Brazilian and international speakers, in some cases with the opportunity for a selected Brazilian early career researcher to engage with the audience by presenting their recent independent career developments.
11:35 Early Career presentation 1 with Q&A
11:55 Main speaker with Q&A
12:55 Early Career presentation 2 with Q&A
13:15 Closing remarks
Dereplication strategy by LC-ESI-MS for rapid identification of natural products in anti-inflammatory and antiprotozoal food by-products and food mixtures.
Food production generates high levels of waste and byproducts, causing a negative environmental impact. However, these biomaterials are a source of valuable compounds such as proteins, lipids, starch, micronutrients, bioactive compounds, and dietary fibers. Banana inflorescences are byproduct of banana cultivation consumed in various regions of Brazil as a non-conventional food. This byproduct represents an alternative food supply that can contribute to minimize nutritional problems and hunger. Banana blossom is also used in Asia as a traditional remedy for the treatment of various illnesses such as bronchitis and dysentery. Because of the lack of chemical and pharmacological data to support its consumption as a functional food, anti-inflammatory action of Musa acuminata blossom was evaluated as well as its antiparasitic activities on the intracellular forms of T. cruzi, L. amazonensis and L. infantum. Since banana blossom showed anti-inflammatory and antiprotozoal activities, their chemical profiles were established by using UPLC-ESI-MS. LCMS data revealed essentially the presence of acetyl arylpropanoids sucroses. Curry powder is a blend of spices that is extensively consumed worldwide and mainly in Central Asia. Its preparation is strictly related to each locality and because of the health benefits of its constituents. However, concerns have been addressed about whether these mixtures of spices conserve their biological properties. Thus, eight commercial forms of this condiment were investigated for their anti-inflammatory and antiparasitic activities. The eight curry powders (1-8) showed different biological profiles. Curry 7 was anti-inflammatory while Currys 2, 6, and 8 were leishmanicidal. They all displayed different LCMS profiles from which various polyphenols, sesquiterpenes, saponins, curcuminoids, aryheptanoids, and triterpenes were characterized.
Professor Airton Salles
Forget the Fancy Stuff: Green 91AV made Simple to Build Interesting Molecules
Finding the right balance between waste, energy efficiency, robustness, recyclability and so on is a relentless pursue in a chemical process. Fulfilling all these criteria is a hard task and we may never achieve a perfect compromise; nevertheless, adepts of Green 91AV are doing their best. In this talk, I will present recent achievements in my group showing that simple experimental setups and reaction conditions can be used to build interesting and complex molecules and follow the guidelines of sustainable chemistry.
Professor Dr Timothy Noël
Combining electrochemical synthetic methodology with flow technology - The best of two worlds?
Electrochemistry constitutes a mild, green and versatile activation method of organic molecules. Despite these innate advantages, its widespread use in organic chemistry has been hampered due to technical limitations, such as mass and heat transfer limitations which restraints the scalability of electrochemical methods. Most of the limitations associated with organic electrochemistry can be overcome by performing electrochemical reactions in continuous-flow microreactors. Specifically, the confined dimensions of micro-flow reactors (up to 1 mm internal diameter) allows to reduce the Ohmic drop, to minimize the total amount of supporting electrolytes, and to increase mass transfer from the bulk solution to the electrode surface.
In this lecture, we will describe the development of an electrochemical flow reactor which allows not only to accelerate electrochemical transformations but also to scale the chemistry without the need for reoptimization of the reaction conditions. We provide insight in the reasons why flow and electrochemistry are a natural match. Finally, the versatility of this reactor is exemplified for a variety of different electrochemical methods, including selective oxidation of thioethers and the synthesis of sulfonamides, sulfonyl fluorides and aziridines.
COVID-19 has exposed us to a new reality where the virtual world is much more important than before. In order to keep our students engaged at the frontiers of Organic 91AV, we have organized a weekly webinar series that is a joint collaboration between the 91AV (RSC) and the Organic 91AV Division of the Brazilian Chemical Society (SBQ). It is an alternative way to share work and interact with potential collaborators.
The sections will alternate between Brazilian and international speakers, in some cases with the opportunity for a selected Brazilian early career researcher to engage with the audience by presenting their recent independent career developments.
Programme
11:30 Introductions and welcome11:35 Early Career presentation 1 with Q&A
11:55 Main speaker with Q&A
12:55 Early Career presentation 2 with Q&A
13:15 Closing remarks
Speakers
Dr. Louis SandjoDereplication strategy by LC-ESI-MS for rapid identification of natural products in anti-inflammatory and antiprotozoal food by-products and food mixtures.
Food production generates high levels of waste and byproducts, causing a negative environmental impact. However, these biomaterials are a source of valuable compounds such as proteins, lipids, starch, micronutrients, bioactive compounds, and dietary fibers. Banana inflorescences are byproduct of banana cultivation consumed in various regions of Brazil as a non-conventional food. This byproduct represents an alternative food supply that can contribute to minimize nutritional problems and hunger. Banana blossom is also used in Asia as a traditional remedy for the treatment of various illnesses such as bronchitis and dysentery. Because of the lack of chemical and pharmacological data to support its consumption as a functional food, anti-inflammatory action of Musa acuminata blossom was evaluated as well as its antiparasitic activities on the intracellular forms of T. cruzi, L. amazonensis and L. infantum. Since banana blossom showed anti-inflammatory and antiprotozoal activities, their chemical profiles were established by using UPLC-ESI-MS. LCMS data revealed essentially the presence of acetyl arylpropanoids sucroses. Curry powder is a blend of spices that is extensively consumed worldwide and mainly in Central Asia. Its preparation is strictly related to each locality and because of the health benefits of its constituents. However, concerns have been addressed about whether these mixtures of spices conserve their biological properties. Thus, eight commercial forms of this condiment were investigated for their anti-inflammatory and antiparasitic activities. The eight curry powders (1-8) showed different biological profiles. Curry 7 was anti-inflammatory while Currys 2, 6, and 8 were leishmanicidal. They all displayed different LCMS profiles from which various polyphenols, sesquiterpenes, saponins, curcuminoids, aryheptanoids, and triterpenes were characterized.
Professor Airton Salles
Forget the Fancy Stuff: Green 91AV made Simple to Build Interesting Molecules
Finding the right balance between waste, energy efficiency, robustness, recyclability and so on is a relentless pursue in a chemical process. Fulfilling all these criteria is a hard task and we may never achieve a perfect compromise; nevertheless, adepts of Green 91AV are doing their best. In this talk, I will present recent achievements in my group showing that simple experimental setups and reaction conditions can be used to build interesting and complex molecules and follow the guidelines of sustainable chemistry.
Professor Dr Timothy Noël
Combining electrochemical synthetic methodology with flow technology - The best of two worlds?
Electrochemistry constitutes a mild, green and versatile activation method of organic molecules. Despite these innate advantages, its widespread use in organic chemistry has been hampered due to technical limitations, such as mass and heat transfer limitations which restraints the scalability of electrochemical methods. Most of the limitations associated with organic electrochemistry can be overcome by performing electrochemical reactions in continuous-flow microreactors. Specifically, the confined dimensions of micro-flow reactors (up to 1 mm internal diameter) allows to reduce the Ohmic drop, to minimize the total amount of supporting electrolytes, and to increase mass transfer from the bulk solution to the electrode surface.
In this lecture, we will describe the development of an electrochemical flow reactor which allows not only to accelerate electrochemical transformations but also to scale the chemistry without the need for reoptimization of the reaction conditions. We provide insight in the reasons why flow and electrochemistry are a natural match. Finally, the versatility of this reactor is exemplified for a variety of different electrochemical methods, including selective oxidation of thioethers and the synthesis of sulfonamides, sulfonyl fluorides and aziridines.
